Gene
nkap
- ID
- ZDB-GENE-030131-8064
- Name
- NFKB activating protein
- Symbol
- nkap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including NKAP (NFKB activating protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151930 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1477Tg | Transgenic insertion | Start Codon | Unknown | DNA | |
| hi2991Tg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| sa11850 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28335 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3216 | Allele with one deletion | Exon 8 | Frameshift | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, X-linked syndromic, Hackman-Di Donato type | 301039 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NF-kappa-B-activating protein | NF-kappa-B-activating protein, C-terminal |
|---|---|---|---|---|
| UniProtKB:Q6DRM1 | InterPro | 368 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31J3 | ZFIN Curated Data | |
| Encodes | EST | fj36d09 | ZFIN Curated Data | |
| Encodes | EST | fj49c09 | ||
| Encodes | EST | IMAGE:7151930 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136458 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194079 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194083 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003414 (1) | 1649 nt | ||
| Genomic | GenBank:BX571981 (2) | 258091 nt | ||
| Polypeptide | UniProtKB:Q6DRM1 (1) | 368 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Amsterdam, et al. (2004. Proc. Natl. Acad. Sci. USA 101:12792-12797) reported this gene to be the ortholog of human NKAPL based on amino acid similarity. Subsequent analysis suggests it is the ortholog of human NKAP and mouse Nkap based on amino acid sequence and conserved synteny.
- Li, L., Huang, J., Feng, L., Xu, L., Lin, H., Liu, K., Li, X., Wang, R. (2024) Altechromone A Ameliorates Inflammatory Bowel Disease by Inhibiting NF-κB and NLRP3 Pathways. Marine drugs. 22(9):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Mi, X., Song, Y., Deng, C., Yan, J., Li, Z., Li, Y., Zheng, J., Yang, W., Gong, L., Shi, J. (2023) Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease. Cellular and molecular gastroenterology and hepatology. 16(5):657-684
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Chen, J., Tchivelekete, G.M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z. (2021) Anti-inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos. Experimental and Therapeutic Medicine. 22:700
- Sireswar, S., Dey, G., Biswas, S. (2021) Influence of fruit-based beverages on efficacy of Lacticaseibacillus rhamnosus GG (Lactobacillus rhamnosus GG) against DSS-induced intestinal inflammation. Food research international (Ottawa, Ont.). 149:110661
- Hang, N.T., Nachtergael, A., Mai, N.T., Cornet, V., Duez, P., Muller, M., Ly Huong, D.T., Kestemont, P. (2020) Anti-inflammatory properties of the ethanol extract from Clerodendrum cyrtophyllum Turcz based on in vitro and in vivo studies. Journal of ethnopharmacology. 254:112739
- Mawed, S.A., He, Y., Zhang, J., Mei, J. (2020) Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish. International Journal of Molecular Sciences. 21(4):
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Nguyen, T.H., Le, H.D., Kim, T.N.T., The, H.P., Nguyen, T.M., Cornet, V., Lambert, J., Kestemont, P. (2020) Anti-Inflammatory and Antioxidant Properties of the Ethanol Extract of Clerodendrum Cyrtophyllum Turcz in Copper Sulfate-Induced Inflammation in Zebrafish. Antioxidants (Basel, Switzerland). 9(3):
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