Gene
sdhb
- ID
- ZDB-GENE-030131-8005
- Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- Symbol
- sdhb Nomenclature History
- Previous Names
-
- fj46d06
- wu:fj46d06
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable iron-sulfur cluster binding activity and ubiquinone binding activity. Acts upstream of or within mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alar plate midbrain region; brain; eye; pronephric duct; and segmental plate. Used to study paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6896418 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carney-Stratakis syndrome | Alliance | Paraganglioma and gastric stromal sarcoma | 606864 |
| gastrointestinal stromal tumor | Alliance | Gastrointestinal stromal tumor | 606764 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 4 | 115310 |
| Mitochondrial complex II deficiency, nuclear type 4 | 619224 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| paraganglioma | sdhbrmc200/rmc200 (AB) | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| Conserved_site | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR025192 | Succinate dehydogenase/fumarate reductase N-terminal |
| Family | IPR004489 | Succinate dehydrogenase/fumarate reductase iron-sulphur protein |
| Family | IPR050573 | Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur |
| Homologous_superfamily | IPR009051 | Alpha-helical ferredoxin |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
Domain Details Per Protein
| Protein | Length | 2Fe-2S ferredoxin, iron-sulphur binding site | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Alpha-helical ferredoxin | Beta-grasp domain superfamily | Succinate dehydogenase/fumarate reductase N-terminal | Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur | Succinate dehydrogenase/fumarate reductase iron-sulphur protein |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A5PL98
|
280 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-sdhb | monoclonal | IgG2a , k | Mouse |
|
MitoSciences
Abcam plc |
6 |
Plasmids
No data available