Gene

sdhb

ID

ZDB-GENE-030131-8005

Name

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Symbol

sdhb Nomenclature History

Previous Names

fj46d06
wu:fj46d06

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have iron-sulfur cluster binding activity and ubiquinone binding activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; paraganglioma; and pheochromocytoma. Is expressed in several structures, including alar plate midbrain region; immature eye; optic tectum; pronephric duct; and segmental plate. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6896418 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sdhb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Carney-Stratakis syndrome	Alliance	Paraganglioma and gastric stromal sarcoma	606864
gastrointestinal stromal tumor	Alliance	Gastrointestinal stromal tumor	606764
paraganglioma	Alliance	Pheochromocytoma/paraganglioma syndrome 4	115310
		Mitochondrial complex II deficiency, nuclear type 4	619224

Associated With sdhb Via Experimental Models

Human Disease	Fish	Conditions	Citations
paraganglioma	sdhb^{rmc200/rmc200} (AB)	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site
Conserved_site	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Domain	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
Domain	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal
Family	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Family	IPR050573	Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur
Homologous_superfamily	IPR009051	Alpha-helical ferredoxin
Homologous_superfamily	IPR012675	Beta-grasp domain superfamily
Homologous_superfamily	IPR036010	2Fe-2S ferredoxin-like superfamily

Domain Details Per Protein

Protein	Length	2Fe-2S ferredoxin, iron-sulphur binding site	2Fe-2S ferredoxin-like superfamily	2Fe-2S ferredoxin-type iron-sulfur binding domain	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Alpha-helical ferredoxin	Beta-grasp domain superfamily	Succinate dehydogenase/fumarate reductase N-terminal	Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur	Succinate dehydrogenase/fumarate reductase iron-sulphur protein
UniProtKB:A5PL98 InterPro	280

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sdhb-201 (1) Ensembl	Ensembl		3,272 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB1-sdhb	monoclonal	sdhb	IgG2a , k	Mouse	IHC WB	Abcam plc MitoSciences	6

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations