Gene
rbp4l
- ID
- ZDB-GENE-030131-7591
- Name
- retinol binding protein 4, like
- Symbol
- rbp4l Nomenclature History
- Previous Names
-
- purpurin (1)
- wu:fk53a11
- zgc:73163
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable retinol binding activity and retinol transmembrane transporter activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in extracellular space. Is expressed in neural crest; visual system; and yolk syncytial layer.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73163 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Nagashima et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44965 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rbp4l | N/A | Nagashima et al., 2009 |
| MO2-rbp4l | N/A | Nagashima et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calycin | Lipocalin, ApoD type | Lipocalin/cytosolic fatty-acid binding domain | Retinol binding protein/Purpurin |
|---|---|---|---|---|---|
|
UniProtKB:Q6PC07
|
196 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30K6 | ZFIN Curated Data | |
| Encodes | EST | fk53a11 | ||
| Encodes | cDNA | MGC:73163 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173979 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173980 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199965 (1) | 854 nt | ||
| Genomic | GenBank:AL844141 (1) | 257634 nt | ||
| Polypeptide | UniProtKB:Q6PC07 (1) | 196 aa |
No data available
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Gemmell, N.J. (2017) Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of reproduction. 99(2):446-460
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
- Konzer, A., Ruhs, A., Braun, H., Jungblut, B., Braun, T., and Krueger, M. (2013) Stable Isotope Labeling in Zebrafish Allows in Vivo Monitoring of Cardiac Morphogenesis. Molecular & cellular proteomics : MCP. 12(6):1502-12
- Nagashima, M., Mawatari, K., Tanaka, M., Higashi, T., Saito, H., Muramoto, K., Matsukawa, T., Koriyama, Y., Sugitani, K., and Kato, S. (2009) Purpurin is a key molecule for cell differentiation during the early development of zebrafish retina. Brain research. 1302:54-63
- Tanaka, M., Murayama, D., Nagashima, M., Higashi, T., Mawatari, K., Matsukawa, T., and Kato, S. (2007) Purpurin expression in the zebrafish retina during early development and after optic nerve lesion in adults. Brain research. 1153(1):34-42
- Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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