ZFIN ID: ZDB-GENE-030131-7513
Gene Name: protein tyrosine phosphatase non-receptor type 6
Gene Symbol: ptpn6
Sequence Ontology ID : SO:0000704

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Previous Names: fj22f05, SHP1 (1), wu:fj22f05 (1)

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(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein tyrosine phosphatase activity; involved in innate immune response; predicted to localize to the cytoplasm; orthologous to human PTPN6 (protein tyrosine phosphatase,  ...
GENE EXPRESSION
All Expression Data: 14 figures from 5 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:55501]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6438 Point Mutation Unknown Splice Site ENU
sa22882 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH ptpn6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ptpn6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process innate immune response (more)
    Cellular Component cytoplasm (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000242 (1)
  • InterPro:IPR000387 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR003595 (1)
  • InterPro:IPR012152 (1)
  • InterPro:IPR016130 (1)
  • InterPro:IPR029021 (1)
  • InterPro:IPR036860 (1)
  • PROSITE:PS00383 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50055 (1)
  • PROSITE:PS50056 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF00102 (1)
  • EC:3.1.3.48 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptpn6-202 (1) 825
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptpn6 No data available
    MARKER RELATIONSHIPS
    ptpn6Contained in: [BAC] CH211-57K11 (1) (order this)
    ptpn6Encodes: [EST] fj22f05
    [cDNA] MGC:55501 (1) (order this), MGC:192937 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199960 (1) 2125bp
    Genomic GenBank:BX511250 (1) 189081bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q2T0 (1) 590aa
    Sequence Clusters UniGene:162021 (1)
    Sequence Information (all 30)
    OTHER ptpn6 GENE PAGES
  • Alliance (1)
  • Gene:335573 (1)
  • VEGA:OTTDARG00000033931 (1)
  • Ensembl(GRCz11):ENSDARG00000089043 (2)
  • ORTHOLOGY for ptpn6 (Chr: 16)
    CITATIONS (37)