Gene

tnksa

ID

ZDB-GENE-030131-7450

Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a

Symbol

tnksa Nomenclature History

Previous Names

TANK1 (1)
tnks1a (1)
tnks
wu:fj17h02

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have NAD+ ADP-ribosyltransferase activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of telomere capping; and protein localization to chromosome, telomeric region. Predicted to localize to cytoplasm and nucleus. Is expressed in brain; dorsal telencephalon; hypothalamus; medulla oblongata; and preoptic area. Orthologous to human TNKS (tankyrase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wang et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wang et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnksa Human Ortholog

No data available

Associated With tnksa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain
Family	IPR051165	Multifunctional Ankyrin Repeat Domain-Containing Protein
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Multifunctional Ankyrin Repeat Domain-Containing Protein	Poly(ADP-ribose) polymerase, catalytic domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily
UniProtKB:A0A8M9PPY2 InterPro	1026
UniProtKB:E9QD73 InterPro	1252
UniProtKB:A0A8M3ALH5 InterPro	1259

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tnksa-201 (1) Ensembl	Ensembl	4,121 nt	Select Tool ZFIN BLAST
mRNA	tnksa-202 (1) Ensembl	Ensembl	4,394 nt	Select Tool
ncRNA	tnksa-002 (1) Ensembl	Ensembl	688 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tnks	polyclonal	tnksa tnksb		Rabbit	IHC	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations