Gene
tubb2b
- ID
- ZDB-GENE-030131-722
- Name
- tubulin, beta 2b
- Symbol
- tubb2b Nomenclature History
- Previous Names
-
- fb40f09
- wu:fb40f09 (1)
- zgc:123194
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness and complex cortical dysplasia with other brain malformations 7. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complex cortical dysplasia with other brain malformations 7 | Alliance | Cortical dysplasia, complex, with other brain malformations 7 | 610031 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017975 | Tubulin, conserved site |
| Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
| Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
| Family | IPR000217 | Tubulin |
| Family | IPR002453 | Beta tubulin |
| Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
| Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
| Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
| Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IPH2 | InterPro | 445 | |||||||||
| UniProtKB:A0A8M1N7Z8 | InterPro | 472 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tubb2b-201
(1)
|
Ensembl | 1,568 nt |
Interactions and Pathways
No data available
Plasmids
No data available