Gene
itgb4
- ID
- ZDB-GENE-030131-7209
- Name
- integrin, beta 4
- Symbol
- itgb4 Nomenclature History
- Previous Names
-
- fl03d06
- wu:fb72e01
- wu:fc27g01
- wu:fl03d06
- zgc:136313 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within several processes, including cell adhesion; cell motility; and hemidesmosome assembly. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| junctional epidermolysis bullosa with pyloric atresia | Alliance | Epidermolysis bullosa, junctional 5B, with pyloric atresia | 226730 |
| Epidermolysis bullosa, junctional 5A, intermediate | 619816 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002369 | Integrin beta subunit, VWA domain |
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR012896 | Integrin beta subunit, tail |
| Domain | IPR016201 | PSI domain |
| Domain | IPR033760 | Integrin beta N-terminal |
| Domain | IPR040622 | Integrin beta, epidermal growth factor-like domain 1 |
| Family | IPR015812 | Integrin beta subunit |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036349 | Integrin beta tail domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
Domain Details Per Protein
| Protein | Length | CalX-like domain superfamily | EGF-like domain | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Integrin beta, epidermal growth factor-like domain 1 | Integrin beta N-terminal | Integrin beta subunit | Integrin beta subunit, tail | Integrin beta subunit, VWA domain | Integrin beta tail domain superfamily | Na-Ca exchanger/integrin-beta4 | PSI domain | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4U0S1
|
1893 | ||||||||||||||
|
UniProtKB:A0A8M2BEB1
|
1931 |
Interactions and Pathways
No data available
Plasmids
No data available