|ZFIN ID: ZDB-PUB-110103-29|
Zebrafish: A Model System to Study Heritable Skin Diseases
Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J.
|Source:||The Journal of investigative dermatology 131(3): 565-571 (Journal)|
|Registered Authors:||Thisse, Bernard, Thisse, Christine|
|PubMed:||21191402 Full text @ J. Invest. Dermatol.|
Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J. (2011) Zebrafish: A Model System to Study Heritable Skin Diseases. The Journal of investigative dermatology. 131(3):565-571.
ABSTRACTHeritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in <500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses. Zebrafish (Danio rerio), a freshwater vertebrate, has a well-characterized genome, the expression of which can be easily manipulated. The larvae develop rapidly, with all major organs having developed by 5-6 days post-fertilization, including the skin, consisting of the epidermis comprising two cell layers and separated from the dermal collagenous matrix by a basement membrane. This perspective highlights the morphological and ultrastructural features of zebrafish skin, in the context of cutaneous gene expression. These observations suggest that zebrafish provide a useful model system to study the molecular aspects of skin development, as well as the pathogenesis and treatment of select heritable skin diseases.