header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-7038
Gene Name: sprouty RTK signaling antagonist 2
Gene Symbol: spry2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fk66h11, wu:fk93e11, zgc:110440

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and midbrain hindbrain boundary neural plate. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
Genome Resources: Alliance (1),  Gene:335098 (1),  Ensembl(GRCz11):ENSDARG00000078308 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013667Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39533 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko92a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spry2 1
    MO1-spry2 N/A 3
    MO2-spry2 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Labalette et al., 2011
    Observed in:
    DISEASE ASSOCIATED WITH spry2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {?IgA nephropathy, susceptibility to, 3} 616818
    DISEASE ASSOCIATED WITH spry2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007875 (1)
  • InterPro:IPR030780 (1)
  • PROSITE:PS51227 (1)
  • Pfam:PF05210 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spry2-201 (1)    Ensembl 2297
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spry2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:spry2-UTRnanos3) UAS nanos3spry2UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    spry2 Contained in: [BAC] DKEY-32C16 (1) (order this)
    spry2 Encodes: [EST] fk66h11, fk93e11
    [cDNA] MGC:110440 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003842 (1)
    Genomic GenBank:CU694659 (1) 170210 bp
    Select Tool
    Polypeptide UniProtKB:F1QU39 (1) 301 aa
    Sequence Clusters UniGene:13009 (1)
    Sequence Information (all 22)
    ORTHOLOGY for spry2 ( Chr: 1 )
    CITATIONS (45)