Gene
spry2
- ID
- ZDB-GENE-030131-7038
- Name
- sprouty RTK signaling antagonist 2
- Symbol
- spry2 Nomenclature History
- Previous Names
-
- wu:fk66h11
- wu:fk93e11
- zgc:110440
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Involved in blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Labalette et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {?IgA nephropathy, susceptibility to, 3} | 616818 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sprouty | Sprouty domain-containing protein |
|---|---|---|---|
|
UniProtKB:F1QU39
|
301 | ||
|
UniProtKB:Q4VBS7
|
301 |
Interactions and Pathways
No data available
Plasmids
No data available