ZFIN ID: ZDB-GENE-030131-7038
Gene Name: sprouty RTK signaling antagonist 2
Gene Symbol: spry2    Nomenclature History

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Previous Names: wu:fk66h11, wu:fk93e11, zgc:110440

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
Genome Resources: Alliance (1),  Gene:335098 (1),  Ensembl(GRCz11):ENSDARG00000078308 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013667Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39533 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko92a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spry2 1
    MO1-spry2 N/A 3
    MO2-spry2 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Labalette et al., 2011
    Observed in:
    DISEASE ASSOCIATED WITH spry2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {?IgA nephropathy, susceptibility to, 3} 616818
    DISEASE ASSOCIATED WITH spry2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spry2-201 (1)    Ensembl 2297
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spry2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:spry2-UTRnanos3) UAS nanos3spry2UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    spry2 Contained in: [BAC] DKEY-32C16 (1) (order this)
    spry2 Encodes: [EST] fk66h11, fk93e11
    [cDNA] MGC:110440 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003842 (1)
    Genomic GenBank:CU694659 (1) 170210 nt
    Select Tool
    Polypeptide UniProtKB:F1QU39 (1) 301 aa
    Sequence Information (all 21)
    ORTHOLOGY for spry2 ( Chr: 1 )
    CITATIONS (47)