Gene
tnfrsf19
- ID
- ZDB-GENE-030131-6760
- Name
- tumor necrosis factor receptor superfamily, member 19
- Symbol
- tnfrsf19 Nomenclature History
- Previous Names
-
- fa04d10
- si:ch211-113p18.2
- wu:fa04d10 (1)
- wu:fk80e07
- zgc:136805
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within establishment of endothelial blood-brain barrier; posterior lateral line neuromast deposition; and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in otic vesicle; posterior lateral line primordium; and tectal ventricle. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012820Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019508Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa742 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6139 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tnfrsf19 | N/A | Tam et al., 2012 |
| MO2-tnfrsf19 | N/A | Tam et al., 2012 |
| MO3-tnfrsf19 | N/A | Han et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 19, N-terminal | Tumor necrosis factor receptor superfamily member 19/27/EDAR | Tumour necrosis factor receptor 19 |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QC14 | InterPro | 330 | ||||
| UniProtKB:Q1ECV9 | InterPro | 356 | ||||
| UniProtKB:A0A8M6YT06 | InterPro | 355 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf19-201
(1)
|
Ensembl | 3,287 nt | ||
| mRNA |
tnfrsf19-202
(1)
|
Ensembl | 727 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tnfrsf19 | polyclonal | Rabbit |
|
LifeSpan BioSciences, Inc.
|
2 | ||
| Ab2-tnfrsf19 | polyclonal | Rabbit |
|
Enzo Life Sciences International, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113P18 | ZFIN Curated Data | |
| Encodes | EST | fa04d10 | ||
| Encodes | EST | fk80e07 | ||
| Encodes | cDNA | MGC:136805 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044904 (1) | 3215 nt | ||
| Genomic | GenBank:AL929082 (1) | 195316 nt | ||
| Polypeptide | UniProtKB:Q1ECV9 (1) | 356 aa |
- Huang, S., Zhang, H., Chen, W., Su, N., Yuan, C., Zhang, J., Xiang, S., Hu, X. (2023) CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes. 14(5):
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Han, H.W., Chou, C.M., Chu, C.Y., Cheng, C.H., Yang, C.H., Hung, C.C., Hwang, P.P., Lee, S.J., Liao, Y.F., and Huang, C.J. (2014) The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One. 9(1):e86345
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tam, S.J., Richmond, D.L., Kaminker, J.S., Modrusan, Z., Martin-McNulty, B., Cao, T.C., Weimer, R.M., Carano, R.A., van Bruggen, N., and Watts, R.J. (2012) Death Receptors DR6 and TROY Regulate Brain Vascular Development. Developmental Cell. 22(2):403-417
- Krol, A.J., Roellig, D., Dequéant, M.L., Tassy, O., Glynn, E., Hattem, G., Mushegian, A., Oates, A.C., and Pourquié, O. (2011) Evolutionary plasticity of segmentation clock networks. Development (Cambridge, England). 138(13):2783-2792
- Abdesselem, H., Shypitsyna, A., Solis, G.P., Bodrikov, V., and Stuermer, C.A. (2009) No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(49):15489-15498
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