Gene

fan1

ID
ZDB-GENE-030131-6225
Name
FANCD2 and FANCI associated nuclease 1
Symbol
fan1 Nomenclature History
Previous Names
  • fi39f01
  • si:ch211-163b1.2
  • si:ch211-201b11.2 (1)
  • wu:fd06a07
  • wu:fi39f01
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-dependent protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair, DNA incision. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in female organism. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fan1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
karyomegalic interstitial nephritis Alliance Interstitial nephritis, karyomegalic 614817
Associated With fan1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006642 Rad18, zinc finger UBZ4-type
Domain IPR014883 VRR-NUC domain
Family IPR033315 Fanconi-associated nuclease 1-like
Homologous_superfamily IPR011856 tRNA endonuclease-like domain superfamily
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Domain Details Per Protein
Protein Length Fanconi-associated nuclease 1-like Rad18, zinc finger UBZ4-type Tetratricopeptide-like helical domain superfamily tRNA endonuclease-like domain superfamily VRR-NUC domain
UniProtKB:A0A2R8QCF4 947
UniProtKB:Q1LWH4 988
UniProtKB:A0A0R4IUX7 988
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations