Gene
ldhd
- ID
- ZDB-GENE-030131-6140
- Name
- lactate dehydrogenase D
- Symbol
- ldhd Nomenclature History
- Previous Names
-
- wu:fi36b04
- zgc:55447
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Involved in lactate catabolic process. Predicted to be active in mitochondrion. Orthologous to human LDHD (lactate dehydrogenase D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55447 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Monroe et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| D-lactic aciduria with susceptibility to gout | 245450 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004113 | FAD-binding oxidoreductase/transferase, type 4, C-terminal |
| Domain | IPR006094 | FAD linked oxidase, N-terminal |
| Domain | IPR016166 | FAD-binding domain, PCMH-type |
| Homologous_superfamily | IPR016164 | FAD-linked oxidase-like, C-terminal |
| Homologous_superfamily | IPR016169 | FAD-binding, type PCMH, subdomain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, PCMH-type | FAD-binding oxidoreductase/transferase, type 4, C-terminal | FAD-binding, type PCMH-like superfamily | FAD-binding, type PCMH, subdomain 2 | FAD-linked oxidase-like, C-terminal | FAD linked oxidase, N-terminal | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QXM5 | InterPro | 497 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197K16 | ZFIN Curated Data | |
| Encodes | EST | fi36b04 | ||
| Encodes | cDNA | MGC:55447 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199873 (1) | 1867 nt | ||
| Genomic | GenBank:CR388073 (2) | 131786 nt | ||
| Polypeptide | UniProtKB:F1QXM5 (1) | 497 aa |
- Monroe, G.R., van Eerde, A.M., Tessadori, F., Duran, K.J., Savelberg, S.M.C., van Alfen, J.C., Terhal, P.A., van der Crabben, S.N., Lichtenbelt, K.D., Fuchs, S.A., Gerrits, J., van Roosmalen, M.J., van Gassen, K.L., van Aalderen, M., Koot, B.G., Oostendorp, M., Duran, M., Visser, G., de Koning, T.J., Calì, F., Bosco, P., Geleijns, K., de Sain-van der Velden, M.G.M., Knoers, N.V., Bakkers, J., Verhoeven-Duif, N.M., van Haaften, G., Jans, J.J. (2019) Identification of human D lactate dehydrogenase deficiency. Nature communications. 10:1477
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ferg, M., Sanges, R., Gehrig, J., Kiss, J., Bauer, M., Lovas, A., Szabo, M., Yang, L., Straehle, U., Pankratz, M.J., Olasz, F., Stupka, E., and Müller, F. (2007) The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. The EMBO journal. 26(17):3945-3956
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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