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Gene

bmp15

ID
ZDB-GENE-030131-6115
Name
bone morphogenetic protein 15
Symbol
bmp15 Nomenclature History
Previous Names
  • fi35a05
  • wu:fi35a05
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable cytokine activity and type I activin receptor binding activity. Acts upstream of or within female sex differentiation; negative regulation of oocyte development; and oocyte maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; female organism; gonad; heart; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and primary ovarian insufficiency. Orthologous to human BMP15 (bone morphogenetic protein 15).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp15 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 2 Alliance Ovarian dysgenesis 2 300510
ovarian dysgenesis 2 Alliance Premature ovarian failure 4 300510
primary ovarian insufficiency 4 Alliance Ovarian dysgenesis 2 300510
primary ovarian insufficiency 4 Alliance Premature ovarian failure 4 300510
Associated With bmp15 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Family IPR015923 Bone morphogenetic protein 15
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Bone morphogenetic protein 15 Cystine-knot cytokine Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q08CT4 384
UniProtKB:Q58FS4 384
UniProtKB:F8W2L1 130
UniProtKB:F1QA78 384
UniProtKB:Q0VG66 394
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-bmp15 polyclonal Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations