tnfrsf21

ID

ZDB-GENE-030131-5971

Name

tumor necrosis factor receptor superfamily, member 21

Symbol

tnfrsf21 Nomenclature History

Previous Names

DR6 (2)
im:6795346
wu:fa55e01 (1)
wu:fb02e11 (1)
wu:fc29a09 (1)
wu:fi27h08 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Acts upstream of or within establishment of endothelial blood-brain barrier and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in floor plate; forerunner cell group; and pronephric duct. Orthologous to human TNFRSF21 (TNF receptor superfamily member 21).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Tam et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnfrsf21 Human Ortholog

No data available

Associated With tnfrsf21 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000488	Death domain
Domain	IPR001368	TNFR/NGFR cysteine-rich region
Domain	IPR034034	Tumor necrosis factor receptor 21, N-terminal
Domain	IPR034037	Tumor necrosis factor receptor 21, death domain
Family	IPR022330	Tumour necrosis factor receptor 21
Homologous_superfamily	IPR011029	Death-like domain superfamily