Gene
zfp36l2
- ID
- ZDB-GENE-030131-5873
- Name
- zinc finger protein 36, C3H type-like 2
- Symbol
- zfp36l2 Nomenclature History
- Previous Names
-
- fi22c11
- wu:fi22c11
- zgc:76924
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable mRNA 3'-UTR AU-rich region binding activity and metal ion binding activity. Acts upstream of or within cranial skeletal system development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in head; post-vent region; telencephalon; and trunk. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sun et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zfp36l2 | Zebrafish Nomenclature Committee | |
| MO1-zfp36l2 | N/A | Sun et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oocyte/zygote/embryo maturation arrest 13 | 620154 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | RNA-binding protein ZFP36-like | Tis11B-like protein, N-terminal | Zinc finger, CCCH-type | Zinc finger, CCCH-type superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NYS5 | InterPro | 310 | ||||
| UniProtKB:F1QU82 | InterPro | 373 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zfp36l2-201
(1)
|
Ensembl | 2,656 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-zfp36l2 | polyclonal | IgG | Rabbit |
|
Proteintech
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-33K1 | ZFIN Curated Data | |
| Encodes | EST | fi22c11 | ||
| Encodes | cDNA | MGC:76924 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207055 (1) | 2656 nt | ||
| Genomic | GenBank:CR847495 (1) | 228142 nt | ||
| Polypeptide | UniProtKB:F1QU82 (1) | 373 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Sun, J., Li, M., Sun, H., Lin, Z., Shi, B., Jia, Z. (2024) Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes. Journal of Human Genetics. 69(3-4):139-144
- Hu, Y.X., Zhu, R.F., Qin, Y.W., Zhao, X.X., Jing, Q. (2020) Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Atherosclerosis. 309:56-64
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Gómez-Marín, C., Tena, J.J., Acemel, R.D., López-Mayorga, M., Naranjo, S., de la Calle-Mustienes, E., Maeso, I., Beccari, L., Aneas, I., Vielmas, E., Bovolenta, P., Nobrega, M.A., Carvajal, J., Gómez-Skarmeta, J.L. (2015) Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proceedings of the National Academy of Sciences of the United States of America. 112(24):7542-7
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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