Gene
myh9a
- ID
- ZDB-GENE-030131-5870
- Name
- myosin, heavy chain 9a, non-muscle
- Symbol
- myh9a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 17 | Alliance | Deafness, autosomal dominant 17 | 603622 |
MYH-9 related disease | Alliance | Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss | 155100 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
kidney disease | AB/EKW + MO1-myh9a | standard conditions | Anderson et al., 2015 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR000048 | IQ motif, EF-hand binding site |
Domain | IPR001609 | Myosin head, motor domain |
Domain | IPR002928 | Myosin tail |
Domain | IPR004009 | Myosin, N-terminal, SH3-like |
Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
Protein | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCY6
|
1954 | |||||||
UniProtKB:A0A8M9PLW1
|
997 | |||||||
UniProtKB:A0A8M1NEM1
|
1961 |
Interactions and Pathways
No data available
Plasmids
No data available