Gene

myh9a

ID
ZDB-GENE-030131-5870
Name
myosin, heavy chain 9a, non-muscle
Symbol
myh9a Nomenclature History
Previous Names
  • myh9
  • myh9l2
  • fi22c04
  • fj85e11
  • wu:fi22c04 (1)
  • wu:fj85e11
  • zgc:162029 (1)
  • zNMHC-IIA (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh9a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
Associated With myh9a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A5PL54 336
UniProtKB:B6ICZ7 950
UniProtKB:A4VCF3 680
UniProtKB:Q56A44 232
UniProtKB:A0A2R8QQT1 950
UniProtKB:F8W3L6 1964
UniProtKB:A0A2R8RPV9 296
UniProtKB:Q7ZW21 1046
UniProtKB:Q561Q7 352
UniProtKB:A1L219 1046
UniProtKB:Q1ECX7 480
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-myh9 polyclonal Rabbit
  • IHC
  • WB
Covance
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations