Gene
myh9a
- ID
- ZDB-GENE-030131-5870
- Name
- myosin, heavy chain 9a, non-muscle
- Symbol
- myh9a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal failure; and proteinuria. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Orthologous to human MYH9 (myosin heavy chain 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 17 | Alliance | Deafness, autosomal dominant 17 | 603622 |
| MYH-9 related disease | Alliance | Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss | 155100 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| kidney disease | AB/EKW + MO1-myh9a | standard conditions | Anderson et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BCY6
|
1954 | ||||||
|
UniProtKB:A0A8M9PLW1
|
997 | ||||||
|
UniProtKB:A0A8M1NEM1
|
1961 |
Interactions and Pathways
No data available
Plasmids
No data available