Gene

rhot1a

ID

ZDB-GENE-030131-5354

Name

ras homolog family member T1a

Symbol

rhot1a Nomenclature History

Previous Names

rhot1
miro1 (1)
wu:fd14e11
wu:fi14a05
zgc:55581
zgc:77063 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have GTP binding activity and GTPase activity. Predicted to be involved in several processes, including Rho protein signal transduction; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Localizes to mitochondrion. Is expressed in fin bud and head. Orthologous to human RHOT1 (ras homolog family member T1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55581 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hollister et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rhot1a Human Ortholog

No data available

Associated With rhot1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR005225	Small GTP-binding domain
Domain	IPR013566	Mitochondrial Rho GTPase 1/3, EF hand associated, type-1
Domain	IPR013567	EF hand associated, type-2
Domain	IPR020860	MIRO domain
Family	IPR001806	Small GTPase
Family	IPR003578	Small GTPase Rho
Family	IPR021181	Mitochondrial Rho GTPase
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	EF-Hand 1, calcium-binding site	EF hand associated, type-2	EF-hand domain	EF-hand domain pair	MIRO domain	Mitochondrial Rho GTPase	Mitochondrial Rho GTPase 1/3, EF hand associated, type-1	P-loop containing nucleoside triphosphate hydrolase	Small GTPase	Small GTPase Rho	Small GTP-binding domain
UniProtKB:A0A8M3B0X9 InterPro	643
UniProtKB:Q6NVC5 InterPro	619
UniProtKB:A0A8M3AQV6 InterPro	660
UniProtKB:A0A8M3B899 InterPro	709

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rhot1a-201 (1) Ensembl	Ensembl	780 nt	Select Tool
mRNA	rhot1a-203 (1) Ensembl	Ensembl	3,064 nt	Select Tool ZFIN BLAST
mRNA	rhot1a-205 (1) Ensembl	Ensembl	2,436 nt	Select Tool
ncRNA	rhot1a-003 (1) Ensembl	Ensembl	738 nt	Select Tool
ncRNA	rhot1a-004 (1) Ensembl	Ensembl	505 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations