Gene
rhot1a
- ID
- ZDB-GENE-030131-5354
- Name
- ras homolog family member T1a
- Symbol
- rhot1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular homeostasis; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Predicted to act upstream of or within small GTPase-mediated signal transduction. Located in mitochondrion. Is expressed in fin bud; head; muscle; and somite. Orthologous to human RHOT1 (ras homolog family member T1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55581 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hollister et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024058Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF hand associated, type-2 | EF-hand domain | EF-hand domain pair | MIRO domain | Mitochondrial Rho GTPase | Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B0X9
|
643 | |||||||||||
|
UniProtKB:Q6NVC5
|
619 | |||||||||||
|
UniProtKB:A0A8M3AQV6
|
660 | |||||||||||
|
UniProtKB:A0A8M3B899
|
709 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rhot1a-201
(1)
|
Ensembl | 780 nt | ||
| mRNA |
rhot1a-203
(1)
|
Ensembl | 3,064 nt | ||
| mRNA |
rhot1a-205
(1)
|
Ensembl | 2,436 nt | ||
| ncRNA |
rhot1a-003
(1)
|
Ensembl | 738 nt | ||
| ncRNA |
rhot1a-004
(1)
|
Ensembl | 505 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-143D15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-156B7 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-455J6 | ZFIN Curated Data | |
| Contains | SNP | rs3727701 | ZFIN Curated Data | |
| Contains | SNP | rs3727702 | ZFIN Curated Data | |
| Encodes | EST | fd14e11 | ||
| Encodes | EST | fi14a05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55581 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77063 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212704 (1) | 3085 nt | ||
| Genomic | GenBank:BX511232 (1) | 171843 nt | ||
| Polypeptide | UniProtKB:A0A8M3B899 (1) | 709 aa |
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Arribat, Y., Grepper, D., Lagarrigue, S., Richard, J., Gachet, M., Gut, P., Amati, F. (2019) Mitochondria in Embryogenesis: An Organellogenesis Perspective. Frontiers in cell and developmental biology. 7:282
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Garcia-Reyero, N., Escalon, L., Prats, E., Faria, M., Soares, A.M., Raldúa, D. (2016) Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bulletin of environmental contamination and toxicology. 96(6):707-713
- Hollister, B.M., Oonk, K.A., Weiser, D.C., Walsh, S. (2016) Characterization of the three zebrafish orthologs of the mitochondrial GTPase Miro/Rhot. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 191:126-34
- Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Salas-Vidal, E., Meijer, A.H., Cheng, X., and Spaink, H.P. (2005) Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86(1):25-37
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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