Gene
gabarapa
- ID
- ZDB-GENE-030131-5174
- Name
- GABA(A) receptor-associated protein a
- Symbol
- gabarapa Nomenclature History
- Previous Names
-
- gabarap
- mg:bb02b03
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GABA receptor binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within brain development. Predicted to be located in membrane. Predicted to be active in autophagosome membrane. Is expressed in central nervous system; eye; and heart. Orthologous to human GABARAP (GABA type A receptor-associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024881Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gabarapa | N/A | Komoike et al., 2010 |
| MO2-gabarapa | N/A | Komoike et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Autophagy protein Atg8 ubiquitin-like | Ubiquitin-like domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q6NZZ7 | InterPro | 163 | ||
| UniProtKB:Q6PSS4 | InterPro | 122 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabarapa-201
(1)
|
Ensembl | 1,315 nt | ||
| ncRNA |
gabarapa-002
(1)
|
Ensembl | 706 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gabarap | polyclonal | Rabbit |
|
1 |
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(CMV:EGFP-gabarapa) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-114C12 | ZFIN Curated Data | |
| Encodes | EST | bb02b03 | ||
| Encodes | EST | IMAGE:6997688 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013260 (1) | 1374 nt | ||
| Genomic | GenBank:AL928875 (2) | 158038 nt | ||
| Polypeptide | UniProtKB:Q6NZZ7 (1) | 163 aa |
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Liu, D., Jiang, Z., Deng, L., Li, H., Jiang, H. (2023) Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Annals of the New York Academy of Sciences. 1526(1):114-125
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
- Widelski, J., Kasica, N., Maciąg, M., Luca, S.V., Budzyńska, B., Fondai, D., Podlasz, P., Skalicka-Woźniak, K. (2023) Simple Coumarins from Peucedanum luxurians Fruits: Evaluation of Anxiolytic Activity and Influence on Gene Expression Related to Anxiety in Zebrafish Model. International Journal of Molecular Sciences. 24(10):
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Wang, H., Qiu, T.X., Lu, J.F., Liu, H.W., Hu, L., Liu, L., Chen, J. (2021) Potential aquatic environmental risks of trifloxystrobin: Enhancement of virus susceptibility in zebrafish through initiation of autophagy. Zoological research. 42:339-349
- Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., Falco, A. (2020) Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports. 10:566
- Enomoto, H., Mittal, N., Inomata, T., Arimura, T., Izumi, T., Kimura, A., Fukuda, K., Makino, S. (2020) Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. Cardiovascular research. 117(4):1118-1131
- Sendra, M., Pereiro, P., Yeste, M.P., Mercado, L., Figueras, A., Novoa, B. (2020) Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism. Environmental pollution (Barking, Essex : 1987). 268:115769
- Librán-Pérez, M., Pereiro, P., Figueras, A., Novoa, B. (2019) Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio). Fish & shellfish immunology. 95:595-605
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