Gene
ttpa
- ID
- ZDB-GENE-030131-4631
- Name
- tocopherol (alpha) transfer protein
- Symbol
- ttpa Nomenclature History
- Previous Names
-
- wu:fd44e05
- zgc:66361
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable lipid transfer activity; phosphatidylinositol bisphosphate binding activity; and vitamin E binding activity. Acts upstream of or within central nervous system development and chordate embryonic development. Predicted to be active in late endosome. Is expressed in several structures, including digestive system; immature eye; nervous system; tail bud; and yolk syncytial layer. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66361 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Miller et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial isolated deficiency of vitamin E | Alliance | Ataxia with isolated vitamin E deficiency | 277460 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | CRAL/TRIO, N-terminal domain | CRAL/TRIO, N-terminal domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B0S5J5
|
285 |
Interactions and Pathways
No data available
Plasmids
No data available