Gene

ttpa

ID
ZDB-GENE-030131-4631
Name
tocopherol (alpha) transfer protein
Symbol
ttpa Nomenclature History
Previous Names
  • wu:fd44e05
  • zgc:66361
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable lipid transfer activity; phosphatidylinositol bisphosphate binding activity; and vitamin E binding activity. Acts upstream of or within central nervous system development and chordate embryonic development. Predicted to be active in late endosome. Is expressed in several structures, including eye; immature eye; liver; neural tube; and tail bud. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Miller et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ttpa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial isolated deficiency of vitamin E Alliance Ataxia with isolated vitamin E deficiency 277460
Associated With ttpa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001251 CRAL-TRIO lipid binding domain
Domain IPR011074 CRAL/TRIO, N-terminal domain
Homologous_superfamily IPR036273 CRAL/TRIO, N-terminal domain superfamily
Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
Domain Details Per Protein
Protein Length CRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily CRAL/TRIO, N-terminal domain CRAL/TRIO, N-terminal domain superfamily
UniProtKB:B0S5J5 285
UniProtKB:Q7SXG2 118
UniProtKB:A0A0R4ITM7 118
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ttpa polyclonal IgG Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations