Gene
tardbpb
- ID
- ZDB-GENE-030131-3777
- Name
- TAR DNA binding protein b
- Symbol
- tardbpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to localize to nucleoplasm and ribonucleoprotein complex. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Is expressed in several structures, including brain; eye; gill; heart; and liver. Orthologous to human TARDBP (TAR DNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu466 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 10 | Alliance | Amyotrophic lateral sclerosis 10, with or without FTD | 612069 |
| amyotrophic lateral sclerosis type 10 | Alliance | Frontotemporal lobar degeneration, TARDBP-related | 612069 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| amyotrophic lateral sclerosis | WT + MO1-tardbpb | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR041105 | TAR DNA-binding protein 43, N-terminal |
| Domain | IPR049124 | TAR DNA-binding protein 43, C-terminal |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAR DNA-binding protein 43, C-terminal | TAR DNA-binding protein 43, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q802C7
|
412 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tardbp-201
(1)
|
Ensembl | 2,798 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tardbp | polyclonal | Rabbit |
|
Proteintech
|
4 | ||
| Ab5-tardbp | monoclonal | IgG2a | Rat |
|
3 | ||
| Ab3-tardbp | polyclonal | Rabbit |
|
Novus Biologicals, LLC
|
2 | ||
| Ab6-tardbp | polyclonal | Rabbit |
|
Sigma-Aldrich
|
4 |
Plasmids
No data available