ZFIN is now using GRCz12tu for Genomic Data
Gene
hmgb1a
- ID
- ZDB-GENE-030131-341
- Name
- high mobility group box 1a
- Symbol
- hmgb1a Nomenclature History
- Previous Names
-
- hmgb1
- ik:tdsubc_1a5
- tdsubc_1a5
- wu:fb23c02
- xx:tdsubc_1a5
- zgc:77104 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity, bending. Acts upstream of or within axon regeneration; forebrain development; and response to cold. Located in plasma membrane. Is expressed in several structures, including blastomere; epidermis; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and congestive heart failure. Orthologous to several human genes including HMGB1 (high mobility group box 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56110 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) | HMG box A DNA-binding domain, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NX86 | InterPro | 205 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgb1a-201
(1)
|
Ensembl | 1,864 nt | ||
| mRNA |
hmgb1a-202
(1)
|
Ensembl | 1,267 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hmgb1a | Rabbit |
|
2 |
Plasmids
No data available
- Genome Browsers