Gene

hmgb1a

ID
ZDB-GENE-030131-341
Name
high mobility group box 1a
Symbol
hmgb1a Nomenclature History
Previous Names
  • hmgb1
  • ik:tdsubc_1a5
  • tdsubc_1a5
  • wu:fb23c02
  • xx:tdsubc_1a5
  • zgc:77104 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have DNA binding activity, bending and transcription factor binding activity. Involved in axon regeneration; forebrain development; and response to cold. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and congestive heart failure. Is expressed in several structures, including blastomere; epidermis; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Orthologous to human HMGB1 (high mobility group box 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hmgb1a Human Ortholog
No data available
Associated With hmgb1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017967 HMG box A DNA-binding domain, conserved site
Domain IPR009071 High mobility group box domain
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily HMG box A DNA-binding domain, conserved site
UniProtKB:Q7ZVC6 205
UniProtKB:Q6NX86 205
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hmgb1a Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations