Gene

fermt1

ID

ZDB-GENE-030131-3264

Name

FERM domain containing kindlin 1

Symbol

fermt1 Nomenclature History

Previous Names

fc32b07
kindlin-1 (1)
si:ch73-22c10.1
wu:fc32b07 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable integrin binding activity. Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within integrin-mediated signaling pathway. Predicted to be active in focal adhesion. Is expressed in several structures, including intestinal epithelium; median fin fold; non neural ectoderm; pectoral fin bud; and pectoral fin fold. Human ortholog(s) of this gene implicated in Kindler syndrome; telangiectasis; and vesiculobullous skin disease. Orthologous to human FERMT1 (FERM domain containing kindlin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Postel et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fermt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Kindler syndrome	Alliance	Kindler syndrome	173650

Associated With fermt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR040790	Kindlin-2, N-terminal
Family	IPR037843	Kindlin/fermitin
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FERM central domain	FERM superfamily, second domain	Kindlin-2, N-terminal	Kindlin/fermitin	PH-like domain superfamily	Pleckstrin homology domain
UniProtKB:E9QBZ4 InterPro	661

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fermt1-201 (1) Ensembl	Ensembl	1,986 nt	Select Tool ZFIN BLAST
mRNA	fermt1-203 (1) Ensembl	Ensembl	415 nt	Select Tool ZFIN BLAST
mRNA	fermt1-204 (1) Ensembl	Ensembl	2,566 nt	Select Tool ZFIN BLAST
ncRNA	fermt1-002 (1) Ensembl	Ensembl	859 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations