Gene

apol1

ID
ZDB-GENE-030131-3217
Name
apolipoprotein L, 1
Symbol
apol1 Nomenclature History
Previous Names
  • si:rp71-1g18.12
  • wu:fa95b12 (1)
  • wu:fc30h04 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have lipid binding activity. Involved in glomerular filtration; glomerular visceral epithelial cell development; and pronephric glomerulus morphogenesis. Predicted to localize to extracellular region and integral component of membrane. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Used to study kidney disease. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis. Orthologous to human APOL1 (apolipoprotein L1); APOL3 (apolipoprotein L3); and APOL5 (apolipoprotein L5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apol1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{End-stage renal disease, nondiabetic, susceptibility to} 612551
{Glomerulosclerosis, focal segmental, 4, susceptibility to} 612551
Associated With apol1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008405 Apolipoprotein L
Domain Details Per Protein
Protein Length Apolipoprotein L
UniProtKB:Q7T131 326
UniProtKB:A0A0R4IKX7 326
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-apol1
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations