Gene
apol1
- ID
- ZDB-GENE-030131-3217
- Name
- apolipoprotein L, 1
- Symbol
- apol1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Acts upstream of or within glomerular filtration; podocyte development; and pronephric glomerulus morphogenesis. Predicted to be located in extracellular region and membrane. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Used to study kidney disease. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1) and APOL4 (apolipoprotein L4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Glomerulosclerosis, focal segmental, 4, susceptibility to} | 612551 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| kidney disease | AB/EKW + MO2-apol1 | standard conditions | Anderson et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008405 | Apolipoprotein L |
Domain Details Per Protein
| Protein | Length | Apolipoprotein L |
|---|---|---|
|
UniProtKB:A0A8M2BIK6
|
440 | |
|
UniProtKB:A0A8M2BIK2
|
464 | |
|
UniProtKB:A0A8M2BJ26
|
465 | |
|
UniProtKB:Q7T131
|
326 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available