ZFIN ID: ZDB-GENE-030131-3003
Gene Name: HNF1 homeobox Bb
Gene Symbol: hnf1bb    Nomenclature History

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Previous Names: hnf1bl (1), hnf1gamma, wu:fc23f06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification involved in pronephros development. Predicted to localize to nucleus. Is expressed in intermediate mesoderm; pronephros; and rhombomere 5. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
Genome Resources: Alliance (1),  Gene:324283 (1),  Ensembl(GRCz11):ENSDARG00000022295 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-hnf1bb N/A 4
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hnf1bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 5 Alliance Renal cysts and diabetes syndrome 137920
nonpapillary renal cell carcinoma Alliance {Renal cell carcinoma} 144700
type 2 diabetes mellitus Alliance Diabetes mellitus, noninsulin-dependent 125853
DISEASE ASSOCIATED WITH hnf1bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process anterior/posterior pattern specification involved in pronephros development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hnf1bb-201 (1)    Ensembl 1439
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hnf1bb No data available
MARKER RELATIONSHIPS
hnf1bb Contained in: [BAC] CH73-7I16 (1)
hnf1bb Encodes: [EST] fc23f06
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_194372 (1) 3575 nt
Genomic GenBank:CU694492 (1) 96581 nt
Select Tool
Polypeptide UniProtKB:Q8UW00 (1) 532 aa
Sequence Information (all 12)
ORTHOLOGY for hnf1bb ( Chr: 21 )
CITATIONS (28)