Gene

hnf1bb

ID
ZDB-GENE-030131-3003
Name
HNF1 homeobox Bb
Symbol
hnf1bb Nomenclature History
Previous Names
  • hnf1bl (1)
  • hnf1gamma
  • wu:fc23f06 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification involved in pronephros development. Predicted to localize to nucleus. Is expressed in intermediate mesoderm; pronephros; and rhombomere 5. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hnf1bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 5 Alliance Renal cysts and diabetes syndrome 137920
nonpapillary renal cell carcinoma Alliance {Renal cell carcinoma} 144700
type 2 diabetes mellitus Alliance Type 2 diabetes mellitus 125853
Associated With hnf1bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminal
Domain IPR006899 Hepatocyte nuclear factor 1, N-terminal
Family IPR039066 Hepatocyte nuclear factor 1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Homologous_superfamily IPR023219 Hepatocyte nuclear factor 1, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Hepatocyte nuclear factor 1 Hepatocyte nuclear factor 1, beta isoform, C-terminal Hepatocyte nuclear factor 1, N-terminal Hepatocyte nuclear factor 1, N-terminal domain superfamily Homeobox domain Homeobox-like domain superfamily Lambda repressor-like, DNA-binding domain superfamily
UniProtKB:F8W5H7 443
UniProtKB:Q8UW00 532
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations