Gene

igf2b

ID

ZDB-GENE-030131-2935

Name

insulin-like growth factor 2b

Symbol

igf2b Nomenclature History

Previous Names

igf2a (1)
fc21h08
wu:fc21h08 (1)
wu:fc34h12 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Exhibits insulin-like growth factor receptor binding activity. Involved in animal organ development; fin regeneration; and somitogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Orthologous to human IGF2 (insulin like growth factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 27 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igf2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Silver-Russell syndrome 3	616489

Associated With igf2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022353	Insulin, conserved site
Domain	IPR013576	Insulin-like growth factor II E-peptide, C-terminal
Domain	IPR016179	Insulin-like
Family	IPR022334	Insulin-like growth factor II
Family	IPR022350	Insulin-like growth factor
Family	IPR022352	Insulin family
Homologous_superfamily	IPR036438	Insulin-like superfamily