Gene

igf2b

ID
ZDB-GENE-030131-2935
Name
insulin-like growth factor 2b
Symbol
igf2b Nomenclature History
Previous Names
  • igf2a (1)
  • fc21h08
  • wu:fc21h08 (1)
  • wu:fc34h12 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Exhibits insulin-like growth factor receptor binding activity. Involved in animal organ development; fin regeneration; and somitogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Orthologous to human IGF2 (insulin like growth factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igf2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Silver-Russell syndrome 3 616489
Associated With igf2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR013576 Insulin-like growth factor II E-peptide, C-terminal
Domain IPR016179 Insulin-like
Family IPR022334 Insulin-like growth factor II
Family IPR022350 Insulin-like growth factor
Family IPR022352 Insulin family
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin, conserved site Insulin family Insulin-like Insulin-like growth factor Insulin-like growth factor II Insulin-like growth factor II E-peptide, C-terminal Insulin-like superfamily
UniProtKB:Q8JIE4 212
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations