Gene
trim33
- ID
- ZDB-GENE-030131-2773
- Name
- tripartite motif containing 33
- Symbol
- trim33 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; transferase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; leukocyte chemotaxis; and regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in chromatin. Is expressed in several structures, including blood vessel; germ ring; gonad; intermediate cell mass of mesoderm; and nervous system. Orthologous to human TRIM33 (tripartite motif containing 33).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1085 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026325Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m62 | unknown | Unknown | Unknown | ENU | |
| m262 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1735 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa2432 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15516 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16614 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27135 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27136 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t30813 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-trim33 | Isiaku et al., 2021 | |
| CRISPR2-trim33 | Isiaku et al., 2021 | |
| MO1-trim33 | N/A | Howard et al., 2010 |
| MO2-trim33 | N/A | (2) |
| MO3-trim33 | N/A | (4) |
| MO4-trim33 | N/A | Demy et al., 2017 |
| MO5-trim33 | N/A | Rossmann et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | B-box, C-terminal | B-box-type zinc finger | Bromodomain | Bromodomain-like superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q2E8
|
1159 | |||||||||||
|
UniProtKB:B0S5U2
|
1176 | |||||||||||
|
UniProtKB:Q6E2N3
|
1163 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trim33-201
(1)
|
Ensembl | 4,048 nt | ||
| mRNA |
trim33-202
(1)
|
Ensembl | 819 nt | ||
| mRNA |
trim33-203
(1)
|
Ensembl | 3,480 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(trim33:trim33) |
|
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-46C9 | ZFIN Curated Data | |
| Encodes | EST | cb1085 | Thisse et al., 2001 | |
| Encodes | EST | fc17f10 | ||
| Encodes | EST | ibd2175 | ||
| Encodes | cDNA | MGC:136680 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002871 (1) | 4049 nt | ||
| Genomic | GenBank:BX321886 (2) | 168093 nt | ||
| Polypeptide | UniProtKB:B0S5U2 (1) | 1176 aa |
- Griffin, M.S., Dahlgren, A.R., Nagaswami, C., Litvinov, R.I., Keeler, K., Madenjian, C., Fuentes, R., Fish, R.J., Neerman-Arbez, M., Holinstat, M., Adili, R., Weisel, J.W., Shavit, J.A. (2023) Composition of thrombi in zebrafish: similarities and distinctions with mammals. Journal of thrombosis and haemostasis : JTH. 22(4):1056-1068
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Demy, D.L., Touret, A.L., Lancino, M., Tauzin, M., Capuana, L., Pierre, C., Herbomel, P. (2022) Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production. Development (Cambridge, England). 149(18):
- Germano, G., Porazzi, P., Felix, C. (2022) Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(10):1728-1740
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Isiaku, A.I., Zhang, Z., Pazhakh, V., Manley, H.R., Thompson, E.R., Fox, L.C., Yerneni, S., Blombery, P., Lieschke, G.J. (2021) Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions. Disease models & mechanisms. 14(7):
- Li, W., Tran, V., Shaked, I., Xue, B., Moore, T., Lightle, R., Kleinfeld, D., Awad, I.A., Ginsberg, M.H. (2021) Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. eLIFE. 10:
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
- Can, H., Chanumolu, S.K., Gonzalez-Muñoz, E., Prukudom, S., Otu, H.H., Cibelli, J.B. (2020) Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. BMC Genomics. 21:471
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