Gene
wnk1b
- ID
- ZDB-GENE-030131-2656
- Name
- WNK lysine deficient protein kinase 1b
- Symbol
- wnk1b Nomenclature History
- Previous Names
-
- wnk1
- fc14f06
- si:ch211-240l19.1
- wu:fc14f06
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Involved in angiogenesis and posterior lateral line neuromast development. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; notochord; posterior lateral line neuromast; and trunk. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1062 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 2A | Alliance | Neuropathy, hereditary sensory and autonomic, type II | 201300 |
| Pseudohypoaldosteronism, type IIC | 614492 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR024678 | Serine/threonine-protein kinase OSR1/WNK, CCT domain |
| Family | IPR050588 | With No Lysine (K) Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Interactions and Pathways
No data available
Plasmids
No data available