Gene
wnk1b
- ID
- ZDB-GENE-030131-2656
- Name
- WNK lysine deficient protein kinase 1b
- Symbol
- wnk1b Nomenclature History
- Previous Names
-
- wnk1
- fc14f06
- si:ch211-240l19.1
- wu:fc14f06
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Acts upstream of or within angiogenesis and posterior lateral line neuromast development. Predicted to be active in cytosol. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; notochord; posterior lateral line neuromast; and trunk. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1062 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 2A | Alliance | Neuropathy, hereditary sensory and autonomic, type II | 201300 |
| Pseudohypoaldosteronism, type IIC | 614492 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR024678 | Serine/threonine-protein kinase OSR1/WNK, CCT domain |
| Family | IPR050588 | With No Lysine (K) Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Interactions and Pathways
No data available
Plasmids
No data available