ZFIN is now using GRCz12tu for Genomic Data

Gene

wnk1b

ID

ZDB-GENE-030131-2656

Name

WNK lysine deficient protein kinase 1b

Symbol

wnk1b Nomenclature History

Previous Names

wnk1
fc14f06
si:ch211-240l19.1
wu:fc14f06

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Acts upstream of or within angiogenesis and posterior lateral line neuromast development. Predicted to be active in cytosol. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; notochord; posterior lateral line neuromast; and trunk. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1062 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wnk1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 2A	Alliance	Neuropathy, hereditary sensory and autonomic, type II	201300
		Pseudohypoaldosteronism, type IIC	614492

Associated With wnk1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Domain	IPR056865	Serine/threonine-protein kinase WNK, CCTL2 domain
Family	IPR050588	With No Lysine (K) Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B8S9	InterPro	2387
UniProtKB:A0A8M9PUZ5	InterPro	1840
UniProtKB:A0A8M3B1I2	InterPro	2463
UniProtKB:A0A8M9P8L7	InterPro	2462
UniProtKB:A0A8M9PJN9	InterPro	2436
UniProtKB:A0A8M9P8M2	InterPro	2442
UniProtKB:A0A8M9Q0Y6	InterPro	2449
UniProtKB:A0A8M9PY05	InterPro	1840
UniProtKB:A0A8M3AR69	InterPro	2456
UniProtKB:A0A8M3AR72	InterPro	2388
UniProtKB:A0A8M3ARF5	InterPro	2442
UniProtKB:A0A8M9PQN2	InterPro	2432
UniProtKB:A0A8M9PQM6	InterPro	2456
UniProtKB:A0A8M3ARF9	InterPro	2035
UniProtKB:A0A8M9PXY8	InterPro	2463
UniProtKB:A0A8M9PHQ7	InterPro	2023
UniProtKB:A0A8M9P8M8	InterPro	2387
UniProtKB:A0A8M9PY00	InterPro	2388
UniProtKB:A0A8M3B8S4	InterPro	2451
UniProtKB:A0A8M9Q1A9	InterPro	2451
UniProtKB:A0A8M3AYK0	InterPro	2418
UniProtKB:A0A8M9PJN1	InterPro	2457
UniProtKB:A0A8M3AYJ7	InterPro	2462
UniProtKB:A0A8M3B1I6	InterPro	2436
UniProtKB:A0A8M6YY71	InterPro	2375
UniProtKB:A0A8M9PXZ3	InterPro	2449
UniProtKB:A0A8M9Q1C0	InterPro	2023
UniProtKB:A0A8M9Q1B5	InterPro	2418
UniProtKB:A0A8M9PQN8	InterPro	2035
UniProtKB:A0A8M9Q681	InterPro	2368
UniProtKB:A0A8M2BBS9	InterPro	2457
UniProtKB:A0A8M9QBQ4	InterPro	2375
UniProtKB:A0A8M9PJP3	InterPro	2368
UniProtKB:A0AC58J9B9	InterPro	2391
UniProtKB:A0AC58J9C0	InterPro	2412
UniProtKB:A0AC58J9C1	InterPro	2444
UniProtKB:A0AC58J9C8	InterPro	2456
UniProtKB:A0AC58J9D0	InterPro	2411
UniProtKB:A0AC58J9D1	InterPro	2370
UniProtKB:A0AC58J9D2	InterPro	2384
UniProtKB:A0AC58J9D3	InterPro	2343
UniProtKB:A0AC58J9D5	InterPro	2381
UniProtKB:A0AC58J9D7	InterPro	2016
UniProtKB:A0AC58J9D8	InterPro	2029
UniProtKB:A0AC58J9D9	InterPro	2325
UniProtKB:A0AC58J9E0	InterPro	2382
UniProtKB:A0AC58J9E1	InterPro	2309
UniProtKB:A0AC58J9E2	InterPro	2022
UniProtKB:A0AC58J9E3	InterPro	2028
UniProtKB:A0AC58J9E4	InterPro	2315
UniProtKB:A0AC58J9E5	InterPro	1984
UniProtKB:A0AC58J9E6	InterPro	1954
UniProtKB:A0AC58J9E7	InterPro	2430
UniProtKB:A0AC58J9E8	InterPro	1948
UniProtKB:A0AC58J9E9	InterPro	1959
UniProtKB:A0AC58J9F0	InterPro	1896
UniProtKB:A0AC58J9F1	InterPro	2017
UniProtKB:A0AC58J9F2	InterPro	1953
UniProtKB:A0AC58J9F3	InterPro	1926
UniProtKB:A0AC58J9F4	InterPro	1947
UniProtKB:A0AC58J9F5	InterPro	1941
UniProtKB:A0AC58J9F7	InterPro	1903
UniProtKB:A0AC58J9F8	InterPro	1960
UniProtKB:A0AC58J9F9	InterPro	1909
UniProtKB:A0AC58J9G1	InterPro	1870
UniProtKB:A0AC58J9G3	InterPro	1888
UniProtKB:A0AC58J9G4	InterPro	1942
UniProtKB:A0AC58J9G5	InterPro	2034
UniProtKB:A0AC58J9G7	InterPro	1897
UniProtKB:A0AC58J9H2	InterPro	1882
UniProtKB:A0AC58J9I6	InterPro	1927

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wnk1b-201 (1) Ensembl	Ensembl	7,074 nt	Select Tool ZFIN BLAST
mRNA	wnk1b-202 (1) Ensembl	Ensembl	660 nt	Select Tool ZFIN BLAST
mRNA	wnk1b-203 (1) Ensembl	Ensembl	562 nt	Select Tool ZFIN BLAST
mRNA	wnk1b-204 (1) Ensembl	Ensembl	10,354 nt	Select Tool ZFIN BLAST
mRNA	wnk1b-205 (1) Ensembl	Ensembl	601 nt	Select Tool ZFIN BLAST
mRNA	wnk1b-206 (1) Ensembl	Ensembl	5,748 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab1-wnk1b	polyclonal	wnk1b		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations