Gene
prickle1b
- ID
- ZDB-GENE-030131-2152
- Name
- prickle homolog 1b
- Symbol
- prickle1b Nomenclature History
- Previous Names
-
- fb98c11
- pk1b (1)
- si:ch211-155a11.1
- wu:fb98c11
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Acts upstream of with a positive effect on motor neuron migration. Acts upstream of or within nervous system development and neural crest cell migration. Predicted to be located in endomembrane system and membrane. Is expressed in several structures, including mesoderm; myotome; nervous system; neuroepithelial cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2482 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh122 | Allele with one point mutation | Unknown | Missense | ENU | |
| la010450Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015329Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015330Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024421Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024422Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024423Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024424Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa40255 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prickle1b | Shah et al., 2015 | |
| MO1-prickle1b | N/A | (8) |
| MO2-prickle1b | N/A | (8) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| progressive myoclonus epilepsy 1B | Alliance | Epilepsy, progressive myoclonic 1B | 612437 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | LIM1 prickle | LIM2 prickle | LIM3 prickle | PET domain | PET prickle | Prickle/Espinas/Testin | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F2Z4V3 | InterPro | 872 | |||||||
| UniProtKB:Q5SP54 | InterPro | 863 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prickle1b-201
(1)
|
Ensembl | 3,335 nt | ||
| mRNA |
prickle1b-202
(1)
|
Ensembl | 922 nt | ||
| mRNA |
prickle1b-203
(1)
|
Ensembl | 3,389 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-155A11 | ZFIN Curated Data | |
| Encodes | EST | eu2482 | Thisse et al., 2005 | |
| Encodes | EST | fb98c11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030098 (1) | 3345 nt | ||
| Genomic | GenBank:AL929504 (2) | 160087 nt | ||
| Polypeptide | UniProtKB:F2Z4V3 (1) | 872 aa |
- Beiriger, A., Narayan, S., Singh, N., Prince, V. (2020) Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. The Journal of comparative neurology. 529(7):1293-1307
- Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:
- Ahsan, K., Singh, N., Rocha, M., Huang, C., Prince, V.E. (2019) Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Developmental Biology. 448(1):16-35
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Nitzan, M., Karaiskos, N., Friedman, N., Rajewsky, N. (2019) Gene expression cartography. Nature. 576(7785):132-137
- McArthur, K.L., Fetcho, J.R. (2017) Key Features of Structural and Functional Organization of Zebrafish Facial Motor Neurons Are Resilient to Disruption of Neuronal Migration. Current biology : CB. 27(12):1746-1756.e5
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chang, J., Skromne, I., Ho, R.K. (2016) CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition. Developmental Biology. 410(2):178-89
- Davey, C.F., Mathewson, A.W., Moens, C.B. (2016) PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. PLoS Genetics. 12:e1005934
- Sun, S.D., Purdy, A.M., Walsh, G.S. (2016) Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neuroscience. 17:83
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