Gene

zbtb16a

ID
ZDB-GENE-030131-1989
Name
zinc finger and BTB domain containing 16a
Symbol
zbtb16a Nomenclature History
Previous Names
  • zbtb16
  • plzfa (1)
  • wu:fb93g12
  • wu:fc07c10
  • zgc:55675
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in positive regulation of type I interferon production and regulation of neurogenesis. Localizes to nucleus. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Wu et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zbtb16a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia, acute promyelocytic, PL2F/RARA type
Associated With zbtb16a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length BTB/POZ domain SKP1/BTB/POZ domain superfamily Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q802Y8 671
UniProtKB:E7FDS7 670
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-zbtb16a polyclonal Rabbit
  • IHC
  • WB
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations