Gene
atp6v0d1
- ID
- ZDB-GENE-030131-1531
- Name
- ATPase H+ transporting V0 subunit d1
- Symbol
- atp6v0d1 Nomenclature History
- Previous Names
-
- cto
- fb73h07
- wu:fb73h07
- zgc:63769
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in cilium assembly and left/right axis specification. Acts upstream of or within several processes, including apical protein localization; pigment granule organization; and sensory system development. Predicted to be located in lysosomal membrane. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase complex. Predicted to be active in early endosome. Predicted to colocalize with centrosome. Is expressed in several structures, including digestive system; integument; nervous system; pleuroperitoneal region; and presumptive retinal pigmented epithelium. Orthologous to human ATP6V0D1 (ATPase H+ transporting V0 subunit d1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63769 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
gw325 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
hi2188bTg | Transgenic insertion | Intron 6 | Unknown | DNA | |
la026014Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa34121 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-atp6v0d1 | N/A | Chen et al., 2012 |
MO2-atp6v0d1 | N/A | Chen et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein | Additional Resources | Length |
---|---|---|
UniProtKB:Q6PGV1 | InterPro | 350 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
atp6v0d1-201
(1)
|
Ensembl | 2,145 nt | ||
mRNA |
atp6v0d1-202
(1)
|
Ensembl | 1,473 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-atp6v0d1 | polyclonal | Mouse |
|
Abnova
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-193L8 | ZFIN Curated Data | |
Encodes | EST | fb73h07 | ||
Encodes | cDNA | MGC:63769 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174003 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199620 (1) | 2134 nt | ||
Genomic | GenBank:CR356247 (2) | 211785 nt | ||
Polypeptide | UniProtKB:Q6PGV1 (1) | 350 aa |
- Levic, D.S., Ryan, S., Marjoram, L., Honeycutt, J., Bagwell, J., Bagnat, M. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. The Journal of cell biology. 219(4):
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, J., Tanguay, R.L., Xiao, Y., Haggard, D.E., Ge, X., Jia, Y., Zheng, Y., Dong, Q., Huang, C., Lin, K. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental pollution (Barking, Essex : 1987). 216:53-63
- Gokey, J.J., Dasgupta, A., Amack, J.D. (2015) The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish. Developmental Biology. 407(1):115-30
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Ramos-Balderas, J.L., Carrillo-Rosas, S., Guzman, A., Navarro, R.E., and Maldonado, E. (2013) The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype. BMC research notes. 6:39
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Chen, Y., Wu, B., Xu, L., Li, H., Xia, J., Yin, W., Li, Z., Li, S., Lin, S., Shu, X., and Pei, D. (2012) A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Research. 22(2):333-345
- Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P. (2012) Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Developmental Biology. 365(2):434-444
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