Gene

map2k5

ID

ZDB-GENE-030131-1517

Name

mitogen-activated protein kinase kinase 5

Symbol

map2k5 Nomenclature History

Previous Names

fb73f02
wu:fb73f02 (1)
zgc:172137 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase activity and protein serine/threonine kinase activity. Involved in brain development. Predicted to localize to cytoplasm. Is expressed in spinal cord. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Jo et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schulte et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map2k5 Human Ortholog

No data available

Associated With map2k5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000270	PB1 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR034851	Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain
Domain	IPR053793	PB1-like domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily