ZFIN ID: ZDB-FIG-141231-4
Schulte et al., 2014 - Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. American journal of human genetics   95:85-95 Full text @ Am. J. Hum. Genet.
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Fig. S5

In vivo complementation and overexpression using human mRNA of MAP2K5, another gene harboring RLS risk alleles identified by means of GWAS3; 4. Suppression of map2k5 results in a reduction of the size of the optic tectum in a similar manner to that seen upon in vivo complementation of MEIS1. Asterisks denote significance levels as determined by Student′s t-test (*** p-value < 0.0001). MO=morpholino, wt=wildtype

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-map2k5 standard conditions Protruding-mouth optic tectum decreased size, abnormal
ZFIN wishes to thank the journal American journal of human genetics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Am. J. Hum. Genet.