Gene
prss59.1
- ID
- ZDB-GENE-030131-1173
- Name
- serine protease 59, tandem duplicate 1
- Symbol
- prss59.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within egg chorion assembly. Predicted to be active in extracellular space. Is expressed in endocrine system; exocrine pancreas; ovary; and pancreas.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66382 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prss59.1 | Rezanujjaman et al., 2024 | |
| MO1-prss59.1 | N/A | Hostelley et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR050127 | Serine Proteases (Peptidase S1 Family) |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R894 | InterPro | 242 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prss59.1-201
(1)
|
Ensembl | 850 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prss59.1 | polyclonal | Mouse |
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-103B2 | ZFIN Curated Data | |
| Encodes | EST | fb61f11 | ||
| Encodes | EST | fb64a04 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:66382 | ZFIN Curated Data | |
| Has Artifact | EST | fb64b08 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199605 (1) | 862 nt | ||
| Genomic | GenBank:FP102797 (1) | 110349 nt | ||
| Polypeptide | UniProtKB:F1R894 (1) | 242 aa |
No data available
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Rezanujjaman, M., Pachoensuk, T., Forhad Hossain, M., Maisum Sarwar Jyoti, M., Rubel Rana, M., Tsutsumi, E., Mouri, T., Bramastri Susilo, M., Wanlada, K., Yamamoto, C., Hasan Ali, M., Tokumoto, T. (2024) Zebrafish prss59.1 is involved in chorion development. General and comparative endocrinology. 349:114453
- Hostelley, T.L., Nesmith, J.E., Larkin, E., Jones, A., Boyes, D., Leitch, C.C., Fontaine, M., Zaghloul, N.A. (2021) Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems. Biology Open. 10(6):
- Rana, R., Hossain, F., Ali, H., Sarwar Jyoti, M., Tokumoto, T. (2021) Biochemical characterization of zebrafish Prss59.1. Biochemical and Biophysical Research Communications. 560:32-36
- Huang, Y., Huang, C.X., Wang, W.F., Liu, H., Wang, H.L. (2020) Zebrafish miR-462-731 is required for digestive organ development. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 34:100679
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Klangnurak, W., Fukuyo, T., Rezanujjaman, M.D., Seki, M., Sugano, S., Suzuki, Y., Tokumoto, T. (2018) Candidate gene identification of ovulation-inducing genes by RNA sequencing with an in vivo assay in zebrafish. PLoS One. 13:e0196544
- DeBofsky, A.R., Klingler, R.H., Mora-Zamorano, F.X., Walz, M., Shepherd, B., Larson, J.K., Anderson, D., Yang, L., Goetz, F., Basu, N., Head, J., Tonellato, P., Armstrong, B.M., Murphy, C., Carvan, M.J. (2017) Female reproductive impacts of dietary methylmercury in yellow perch (Perca flavescens) and zebrafish (Danio rerio). Chemosphere. 195:301-311
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 17:318
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