Gene
ctsla
- ID
- ZDB-GENE-030131-106
- Name
- cathepsin La
- Symbol
- ctsla Nomenclature History
- Previous Names
-
- ctsl1a
- cb143 (1)
- hm:zeh1631
- ik:tdsubc_2d2
- ik:tdsubc_2f10
- sb:cb143
- tdsubc_2f10
- wu:fb70e06
- wu:fi15c08
- xx:tdsubc_2d2
- xx:tdsubc_2f10
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Is expressed in blood; gill; liver; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human CTSL (cathepsin L).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb143 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BCJ2
|
363 | ||||||||
|
UniProtKB:Q6NYR5
|
337 | ||||||||
|
UniProtKB:A5WVL6
|
337 |
Interactions and Pathways
No data available
Plasmids
No data available