Gene
ctsla
- ID
- ZDB-GENE-030131-106
- Name
- cathepsin La
- Symbol
- ctsla Nomenclature History
- Previous Names
-
- ctsl1a
- cb143 (1)
- hm:zeh1631
- ik:tdsubc_2d2
- ik:tdsubc_2f10
- sb:cb143
- tdsubc_2f10
- wu:fb70e06
- wu:fi15c08
- xx:tdsubc_2d2
- xx:tdsubc_2f10
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in blood; gill; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb143 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BCJ2
|
363 | ||||||||
|
UniProtKB:Q6NYR5
|
337 | ||||||||
|
UniProtKB:A5WVL6
|
337 |
Interactions and Pathways
No data available
Plasmids
No data available