Gene
nfe2
- ID
- ZDB-GENE-030124-1
- Name
- nuclear factor, erythroid 2
- Symbol
- nfe2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Acts upstream of or within several processes, including otic vesicle morphogenesis; regulation of primitive erythrocyte differentiation; and swim bladder inflation. Part of transcription regulator complex. Is expressed in blood; otic placode; otic vesicle; ventral mesenchyme; and ventral mesoderm. Orthologous to human NFE2 (nuclear factor, erythroid 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu729 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nfe2 | (2) | |
| MO1-nfe2 | N/A | (2) |
| MO2-nfe2 | N/A | (2) |
| MO3-nfe2 | N/A | Zhang et al., 2015 |
| TALEN1-nfe2 | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004826 | Basic leucine zipper domain, Maf-type |
| Domain | IPR004827 | Basic-leucine zipper domain |
| Family | IPR047167 | Nuclear Factor Erythroid-derived 2-like |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Basic-leucine zipper domain superfamily | Nuclear Factor Erythroid-derived 2-like | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B990 | InterPro | 466 | |||||
| UniProtKB:Q7ZZR2 | InterPro | 419 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-174K1 | ZFIN Curated Data | |
| Encodes | EST | eu729 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193768 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193781 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_175043 (1) | 1331 nt | ||
| Genomic | GenBank:BX571773 (2) | 135439 nt | ||
| Polypeptide | UniProtKB:A0A8M2B990 (1) | 466 aa |
- Xu, Y., Luo, L., Chen, J. (2022) Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling. Ecotoxicology and environmental safety. 238:113620
- Yang, L., Wu, L., Meng, P., Zhang, X., Zhao, D., Lin, Q., Zhang, Y. (2022) Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(8):1900-1909
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Lin, Q., Zhou, R., Meng, P., Wu, L., Yang, L., Liu, W., Wu, J., Cheng, Y., Shi, L., Zhang, Y. (2021) Establishment of a Bernard-Soulier syndrome model in zebrafish. Haematologica. 107(7):1655-1668
- Sant, K.E., Moreau, H.M., Williams, L.M., Jacobs, H.M., Bowsher, A.M., Boisvert, J.D., Smolowitz, R.M., Pantazis, J., Annunziato, K., Nguyen, M., Timme-Laragy, A. (2020) Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease. 12(1):132-140
- Hu, Z., Lavik, K.I., Liu, Y., Vo, A.H., Richter, C.E., Di Paola, J., Shavit, J.A. (2019) Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia. Journal of thrombosis and haemostasis : JTH. 17(4):607-617
- Jiang, J., Lv, L., Wu, S., An, X., Wang, F., Liu, X., Zhao, X. (2018) Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development. Chemosphere. 219:517-525
- Jiang, J., Shi, Y., Yu, R., Chen, L., Zhao, X. (2018) Biological response of zebrafish after short-term exposure to azoxystrobin. Chemosphere. 202:56-64
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Rost, M.S., Shestopalov, I., Liu, Y., Vo, A.H., Richter, C.E., Emly, S.M., Barrett, F.G., Stachura, D.L., Holinstat, M., Zon, L.I., Shavit, J.A. (2018) Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood advances. 2:3418-3427
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