Gene

nfe2

ID

ZDB-GENE-030124-1

Name

nuclear factor, erythroid 2

Symbol

nfe2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including otic vesicle morphogenesis; regulation of primitive erythrocyte differentiation; and swim bladder inflation. Localizes to transcription factor complex. Is expressed in blood; otic placode; otic vesicle; ventral mesenchyme; and ventral mesoderm. Orthologous to human NFE2 (nuclear factor, erythroid 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu729 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfe2 Human Ortholog

No data available

Associated With nfe2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004826	Basic leucine zipper domain, Maf-type
Domain	IPR004827	Basic-leucine zipper domain
Family	IPR029853	Transcription factor NF-E2, 45kDa subunit
Homologous_superfamily	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily