ZFIN is now using GRCz12tu for Genomic Data
Gene
ttk
- ID
- ZDB-GENE-030123-1
- Name
- ttk protein kinase
- Symbol
- ttk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of exit from mitosis and tissue regeneration. Acts upstream of or within anatomical structure homeostasis; fin regeneration; and meiotic chromosome segregation. Predicted to be active in kinetochore and nucleus. Is expressed in caudal fin and proliferative region. Orthologous to human TTK (TTK protein kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64151 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR027084 | Protein kinase Mps1 family, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Protein kinase Mps1 family, catalytic domain | Serine/threonine-protein kinase, active site | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B4P6 | InterPro | 982 | ||||||
| UniProtKB:F1R3H9 | InterPro | 982 | ||||||
| UniProtKB:Q8AYG3 | InterPro | 982 | ||||||
| UniProtKB:A0AB32T4K0 | InterPro | 981 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers