Gene

gapdh

ID

ZDB-GENE-030115-1

Name

glyceraldehyde-3-phosphate dehydrogenase

Symbol

gapdh Nomenclature History

Previous Names

gapd (1)
bb02e05
cb609 (1)
mg:bb02e05
wu:fb33a10
wu:ft80f05

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; microtubule binding activity; and peptidyl-cysteine S-nitrosylase activity. Predicted to be involved in several processes, including glycolytic process; peptidyl-cysteine S-trans-nitrosylation; and protein stabilization. Predicted to localize to cytosol; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including cardiovascular system; integument; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

43 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb609 (28 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gapdh Human Ortholog

No data available

Associated With gapdh Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020830	Glyceraldehyde 3-phosphate dehydrogenase, active site
Domain	IPR020828	Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
Domain	IPR020829	Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
Family	IPR006424	Glyceraldehyde-3-phosphate dehydrogenase, type I
Family	IPR020831	Glyceraldehyde/Erythrose phosphate dehydrogenase family
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	Glyceraldehyde 3-phosphate dehydrogenase, active site	Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain	Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain	Glyceraldehyde-3-phosphate dehydrogenase, type I	Glyceraldehyde/Erythrose phosphate dehydrogenase family	NAD(P)-binding domain superfamily
UniProtKB:Q5XJ10 InterPro	333

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gapdh-201 (1) Ensembl	Ensembl	1,331 nt	Select Tool
mRNA	gapdh-202 (1) Ensembl	Ensembl	445 nt	Select Tool
mRNA	gapdh-203 (1) Ensembl	Ensembl	825 nt	Select Tool
mRNA	gapdh-204 (1) Ensembl	Ensembl	902 nt	Select Tool
mRNA	gapdh-206 (1) Ensembl	Ensembl	4,585 nt	Select Tool ZFIN BLAST
ncRNA	gapdh-005 (1) Ensembl	Ensembl	834 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab6-gapdh	polyclonal	gapdh		Rabbit		GeneTex	3
Ab1-gapdh	monoclonal	gapdh		Mouse	WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations