ZFIN ID: ZDB-GENE-030103-2
Gene Name: phosphate regulating endopeptidase homolog, X-linked
Gene Symbol: phex    Nomenclature History

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Previous Name: wu:fx03e08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Is expressed in lapillus. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked).
Genome Resources: Alliance (1),  Gene:386969 (1),  Ensembl(GRCz11):ENSDARG00000062363 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH phex HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked dominant hypophosphatemic rickets Alliance Hypophosphatemic rickets, X-linked dominant 307800
DISEASE ASSOCIATED WITH phex VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component integral component of membrane (more)
Molecular Function metalloendopeptidase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000718 Peptidase M13
Domain IPR008753 Peptidase M13, N-terminal domain
Domain IPR018497 Peptidase M13, C-terminal domain
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR042089 Peptidase M13, domain 2
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA phex-201 (1)    Ensembl 2640
phex-203 (1)    Ensembl 912
ncRNA phex-003 (1)    Ensembl 879
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM phex No data available
MARKER RELATIONSHIPS
phex Contained in: [BAC] DKEY-225N3 (1) (order this)
phex Encodes: [EST] fx03e08, IMAGE:7151798
[cDNA] MGC:162949 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001089349 (1) 2666 bp
Genomic GenBank:BX537285 (1) 150691 bp
Select Tool
Polypeptide UniProtKB:F1R6K1 (1) 745 aa
Sequence Information (all 21)
ORTHOLOGY for phex ( Chr: 24 )
CITATIONS (32)