ZFIN ID: ZDB-GENE-021226-1
Gene Name: laminin, beta 1a
Gene Symbol: lamb1a    Nomenclature History

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Previous Names: lamb1, cb95 (1), fc20b05, grumpy, gup, sb:cb95, wu:fc20b05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in several processes, including animal organ development; detection of light stimulus involved in visual perception; and fin regeneration. Predicted to localize to laminin complex. Is expressed in several structures, including digestive system; fin; nervous system; optic cup; and pectoral fin bud. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly. Orthologous to human LAMB1 (laminin subunit beta 1).
Genome Resources: Alliance (1),  Gene:286830 (1),  Ensembl(GRCz11):ENSDARG00000101209 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1113bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1297Tg Transgenic Insertion Intron 1 Unknown DNA
    hi3181Tg Transgenic Insertion Intron 1 Unknown DNA
    lamb1a_unspecified Unspecified Unknown Unknown
    m135 Unknown Unknown Unknown ENU
    m189 Point Mutation Unknown Premature Stop ENU
    m217 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m726 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m753 Unknown Unknown Unknown ENU
    pd110 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw65 Unknown Unknown Unknown
    s804 Point Mutation Donor Splice Site of Exon 24 Splice Site, Frameshift ENU
    sa11145 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa38110 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tg210 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ti228b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj229a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl17b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm61 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp42 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx221 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lamb1a N/A 4
    MO2-lamb1a N/A 1
    PHENOTYPE
    Data: 54 figures from 22 publications
    Observed in:
    DISEASE ASSOCIATED WITH lamb1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lissencephaly Alliance Lissencephaly 5 615191
    DISEASE ASSOCIATED WITH lamb1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    coloboma lamb1am189/m189 standard conditions Moosajee et al., 2008
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component laminin complex (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lamb1a-201 (1)    Ensembl 1654
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lamb1a No data available
    MARKER RELATIONSHIPS
    lamb1a Contained in: [Fosmid] CH1073-332D23 (1)
    lamb1a Encodes: [EST] cb95 (order this), fc20b05 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173275 (1) 5358 nt
    Genomic GenBank:CU929267 (1) 37889 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IDN1 (1) 1785 aa
    Sequence Information (all 22)
    ORTHOLOGY for lamb1a ( Chr: 25 )
    CITATIONS (70)