ZFIN is now using GRCz12tu for Genomic Data
Gene
f7i
- ID
- ZDB-GENE-021206-10
- Name
- coagulation factor VIIi
- Symbol
- f7i Nomenclature History
- Previous Names
-
- factor VII-like gene
- fb61d02
- wu:fb61d02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within negative regulation of blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Family | IPR050442 | Peptidase S1 family, coagulation factors |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1 family, coagulation factors | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QPL4 | InterPro | 443 | ||||||||||||
| UniProtKB:F1QZK5 | InterPro | |||||||||||||
| UniProtKB:Q8JHC9 | InterPro | 443 | ||||||||||||
| UniProtKB:A0A8N7UZT1 | InterPro | 443 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers