Gene
aldh3b1
- ID
- ZDB-GENE-021120-3
- Name
- aldehyde dehydrogenase 3 family, member B1
- Symbol
- aldh3b1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Predicted to be active in cytoplasm. Is expressed in EVL; ectoderm; epidermis; peripheral olfactory organ; and pharynx. Orthologous to several human genes including ALDH3B1 (aldehyde dehydrogenase 3 family member B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb508 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024139Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11770 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Family | IPR012394 | Aldehyde dehydrogenase NAD(P)-dependent |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase NAD(P)-dependent | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90ZZ7 | InterPro | 473 | ||||||
| UniProtKB:Q7ZU10 | InterPro | 473 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh3b1-201
(1)
|
Ensembl | 1,985 nt | ||
| mRNA |
aldh3b1-202
(1)
|
Ensembl | 931 nt | ||
| mRNA |
aldh3b1-203
(1)
|
Ensembl | 1,835 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-204F11 | ||
| Encodes | EST | cb508 | Thisse et al., 2001 | |
| Encodes | EST | fb17d04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56651 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173221 (1) | 1960 nt | ||
| Genomic | GenBank:BX649502 (1) | 247387 nt | ||
| Polypeptide | UniProtKB:Q7ZU10 (1) | 473 aa |
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Duan, J., Yu, Y., Li, Y., Jing, L., Yang, M., Wang, J., Li, Y., Zhou, X., Miller, M.R., Sun, Z. (2017) Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model.. The Science of the total environment. 586:666-674
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892
- Holmes, R.S., and Hempel, J. (2011) Comparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. Chemico-biological interactions. 191(1-3):113-121
- Ma, A.C., Chung, M.I., Liang, R., and Leung, A.Y. (2010) A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 24(12):2090-2099
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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