Gene

sec31a

ID

ZDB-GENE-020919-2

Name

SEC31 homolog A, COPII coat complex component

Symbol

sec31a Nomenclature History

Previous Names

sec31p
cb354 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable structural molecule activity. Acts upstream of or within digestive system development; endoplasmic reticulum organization; and liver development. Predicted to be located in COPII-coated ER to Golgi transport vesicle. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including alar plate midbrain region; axis; digestive system; fin; and midbrain. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb354 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Niu et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sec31a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Halperin-Birk syndrome	Alliance	?Halperin-Birk syndrome	618651

Associated With sec31a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR040251	Protein transport protein SEC31-like
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Protein transport protein SEC31-like	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3B600 InterPro	1543
UniProtKB:A0A8M3BCT3 InterPro	1437
UniProtKB:A0A8M3B316 InterPro	1531
UniProtKB:A0A8M9QKI6 InterPro	1405
UniProtKB:Q7SYD5 InterPro	1254
UniProtKB:A0A8M3AWG1 InterPro	1546
UniProtKB:A0A8M3AWH9 InterPro	1526
UniProtKB:A0A8M3BCS9 InterPro	1558
UniProtKB:F1R5G5 InterPro	1250