Gene
id2a
- ID
- ZDB-GENE-020910-1
- Name
- inhibitor of DNA binding 2a
- Symbol
- id2a Nomenclature History
- Previous Names
-
- id2
- cb321 (1)
- wu:fa04e03
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Involved in BMP signaling pathway. Acts upstream of or within several processes, including mitotic intra-S DNA damage checkpoint signaling; regulation of Notch signaling pathway; and regulation of cell proliferation involved in compound eye morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; immature eye; mesoderm; and neural crest. Orthologous to human ID2 (inhibitor of DNA binding 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb321 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-id2a | Mi et al., 2023 | |
| MO1-id2a | N/A | (6) |
| TALEN1-id2a | Choi et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-binding protein inhibitor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q7SZQ2 | InterPro | 137 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:id2a-IRES-EGFP-CAAX) |
|
| Uribe et al., 2010 | ||
| Tg(id2a:GFP-CAAX) |
|
| 1 | Wopat et al., 2018 | |
| Tg(UAS:ida2a,cryaa:Cerulean) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-359P8 | ZFIN Curated Data | |
| Encodes | EST | cb321 | Thisse et al., 2001 | |
| Encodes | EST | fa04e03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66023 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201291 (1) | 1524 nt | ||
| Genomic | GenBank:CT737254 (2) | 80605 nt | ||
| Polypeptide | UniProtKB:Q7SZQ2 (1) | 137 aa |
- Ibarra-García-Padilla, R., Nambiar, A., Hamre, T.A., Singleton, E.W., Uribe, R.A. (2024) Expansion of a neural crest gene signature following ectopic MYCN expression in sympathoadrenal lineage cells in vivo. PLoS One. 19:e0310727e0310727
- Lee, S., Memon, A., Chae, S.C., Shin, D., Choi, T.Y. (2024) Epcam regulates intrahepatic bile duct reconstruction in zebrafish, providing a potential model for primary cholangitis model. Biochemical and Biophysical Research Communications. 696:149512149512
- Mi, J., Andersson, O. (2023) Efficient knock-in method enabling lineage tracing in zebrafish. Life science alliance. 6(5)
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Ma, J., Huang, Y., Jiang, P., Liu, Z., Luo, Q., Zhong, K., Yuan, W., Meng, Y., Lu, H. (2021) Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos. Aquatic toxicology (Amsterdam, Netherlands). 237:105870
- Meng, Y., Zhong, K., Chen, S., Huang, Y., Wei, Y., Wu, J., Liu, J., Xu, Z., Guo, J., Liu, F., Lu, H. (2021) Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. 222:112514
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
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