Gene

myo7aa

ID

ZDB-GENE-020709-1

Name

myosin VIIAa

Symbol

myo7aa Nomenclature History

Previous Names

myo7a
mar
mariner

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception; neuron differentiation; and protein localization to cilium. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Is expressed in brain; otic vesicle; sensory system; and tether cell. Orthologous to human MYO7A (myosin VIIA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo7aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 11	Alliance	Deafness, autosomal dominant 11	601317
autosomal recessive nonsyndromic deafness 2	Alliance	Deafness, autosomal recessive 2	600060
Usher syndrome type 1	Alliance	Usher syndrome, type 1B	276900

Associated With myo7aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
Usher syndrome type 1	myo7aa^{tc320b/tc320b}	standard conditions	Riley et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000299	FERM domain
Domain	IPR000857	MyTH4 domain
Domain	IPR001452	SH3 domain
Domain	IPR002404	IRS-type PTB domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR036106	Class VII myosin, motor domain
Domain	IPR041793	Myosin VII, FERM domain C-lobe, repeat 1
Domain	IPR041794	Myosin VII, FERM domain C-lobe, repeat 2
Family	IPR051567	Unconventional Myosin ATPase
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Homologous_superfamily	IPR038185	MyTH4 domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	Class VII myosin, motor domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	IQ motif, EF-hand binding site	IRS-type PTB domain	Kinesin motor domain superfamily	Myosin VII, FERM domain C-lobe, repeat 1	Myosin VII, FERM domain C-lobe, repeat 2	MyTH4 domain	MyTH4 domain superfamily	PH-like domain superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Ubiquitin-like domain superfamily	Unconventional Myosin ATPase
UniProtKB:A0A8M9P9W0 InterPro	2185
UniProtKB:Q9DGG9 InterPro	2179

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo7aa-201 (1) Ensembl	Ensembl	6,781 nt	Select Tool ZFIN BLAST
mRNA	myo7aa-202 (1) Ensembl	Ensembl	7,561 nt	Select Tool ZFIN BLAST
mRNA	myo7aa-203 (1) Ensembl	Ensembl	6,651 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab1-myo7aa	polyclonal	myo7aa		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations