Gene
myo7aa
- ID
- ZDB-GENE-020709-1
- Name
- myosin VIIAa
- Symbol
- myo7aa Nomenclature History
- Previous Names
-
- myo7a
- mar
- mariner
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception; neuron differentiation; and protein localization to cilium. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Is expressed in brain; otic vesicle; sensory system; and tether cell. Orthologous to human MYO7A (myosin VIIA).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 11 | Alliance | Deafness, autosomal dominant 11 | 601317 |
autosomal recessive nonsyndromic deafness 2 | Alliance | Deafness, autosomal recessive 2 | 600060 |
Usher syndrome type 1 | Alliance | Usher syndrome, type 1B | 276900 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Usher syndrome type 1 | myo7aatc320b/tc320b | standard conditions | Riley et al., 2023 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR000048 | IQ motif, EF-hand binding site |
Domain | IPR000299 | FERM domain |
Domain | IPR000857 | MyTH4 domain |
Domain | IPR001452 | SH3 domain |
Domain | IPR002404 | IRS-type PTB domain |
Domain | IPR019748 | FERM central domain |
Domain | IPR019749 | Band 4.1 domain |
Domain | IPR036106 | Class VII myosin, motor domain |
Domain | IPR041793 | Myosin VII, FERM domain C-lobe, repeat 1 |
Domain | IPR041794 | Myosin VII, FERM domain C-lobe, repeat 2 |
Family | IPR051567 | Unconventional Myosin ATPase |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Homologous_superfamily | IPR038185 | MyTH4 domain superfamily |
Domain Details Per Protein
Protein | Length | Band 4.1 domain | Class VII myosin, motor domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM domain | FERM superfamily, second domain | IQ motif, EF-hand binding site | IRS-type PTB domain | Kinesin motor domain superfamily | Myosin VII, FERM domain C-lobe, repeat 1 | Myosin VII, FERM domain C-lobe, repeat 2 | MyTH4 domain | MyTH4 domain superfamily | PH-like domain superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Ubiquitin-like domain superfamily | Unconventional Myosin ATPase |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9P9W0
|
2185 | |||||||||||||||||||
UniProtKB:Q9DGG9
|
2179 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
myo7aa-201
(1)
|
Ensembl | 6,781 nt | ||
mRNA |
myo7aa-202
(1)
|
Ensembl | 7,561 nt | ||
mRNA |
myo7aa-203
(1)
|
Ensembl | 6,651 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
ab1-myo7aa | polyclonal | Rabbit |
|
1 |
Plasmids
No data available