Gene

myo7aa

ID

ZDB-GENE-020709-1

Name

myosin VIIAa

Symbol

myo7aa Nomenclature History

Previous Names

myo7a
mar
mariner

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including auditory behavior; neuron differentiation; and regulation of Rho protein signal transduction. Predicted to be located in cytoskeleton and plasma membrane bounded cell projection. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and microvillus. Is expressed in brain; otic vesicle; sensory system; and tether cell. Used to study Usher syndrome type 1. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo7aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 11	Alliance	Deafness, autosomal dominant 11	601317
autosomal recessive nonsyndromic deafness 2	Alliance	Deafness, autosomal recessive 2	600060
Usher syndrome type 1	Alliance	Usher syndrome, type 1B	276900

Associated With myo7aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
Usher syndrome type 1	myo7aa^{tc320b/tc320b}	standard conditions	Riley et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000299	FERM domain
Domain	IPR000857	MyTH4 domain
Domain	IPR001452	SH3 domain
Domain	IPR001609	Myosin head, motor domain-like
Domain	IPR002404	IRS-type PTB domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR036106	Class VII myosin, motor domain
Domain	IPR041793	Myosin VII, FERM domain C-lobe, repeat 1
Domain	IPR041794	Myosin VII, FERM domain C-lobe, repeat 2
Family	IPR051567	Unconventional Myosin ATPase
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Homologous_superfamily	IPR038185	MyTH4 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9P9W0	InterPro	2185
UniProtKB:Q9DGG9	InterPro	2179
UniProtKB:A0AB32T794	InterPro	2232

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo7aa-201 (1) Ensembl	Ensembl	6,781 nt	Select Tool ZFIN BLAST
mRNA	myo7aa-202 (1) Ensembl	Ensembl	7,561 nt	Select Tool ZFIN BLAST
mRNA	myo7aa-203 (1) Ensembl	Ensembl	6,651 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab1-myo7aa	polyclonal	myo7aa		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations