Gene
ahr1a
- ID
- ZDB-GENE-020531-2
- Name
- aryl hydrocarbon receptor 1a
- Symbol
- ahr1a Nomenclature History
- Previous Names
-
- ahr1
- AHR2 (1)
- ahra
- zfAHR1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Acts upstream of or within cellular response to organic cyclic compound. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex and transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; female organism; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (aryl hydrocarbon receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Seifinejad et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 85 | Alliance | ?Retinitis pigmentosa 85 | 618345 |
| Foveal hypoplasia 3 | 620958 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Family | IPR039091 | Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8QGQ3
|
805 | ||||||||
|
UniProtKB:A0A8M9NZ29
|
798 | ||||||||
|
UniProtKB:A0A8N7UZF6
|
787 |
Interactions and Pathways
No data available
Plasmids
No data available