Gene
gpia
- ID
- ZDB-GENE-020513-2
- Name
- glucose-6-phosphate isomerase a
- Symbol
- gpia Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to act upstream of or within carbohydrate derivative metabolic process. Predicted to be located in extracellular space. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 4; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55667 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 4 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 4, glucose phosphate isomerase deficient | 613470 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018189 | Phosphoglucose isomerase, conserved site |
| Domain | IPR035476 | Phosphoglucose isomerase, SIS domain 1 |
| Domain | IPR035482 | Phosphoglucose isomerase, SIS domain 2 |
| Family | IPR001672 | Phosphoglucose isomerase (PGI) |
| Homologous_superfamily | IPR023096 | Phosphoglucose isomerase, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphoglucose isomerase, conserved site | Phosphoglucose isomerase, C-terminal | Phosphoglucose isomerase (PGI) | Phosphoglucose isomerase, SIS domain 1 | Phosphoglucose isomerase, SIS domain 2 | SIS domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8QFU2 | InterPro | 553 | ||||||
| UniProtKB:A0A8M1PDD1 | InterPro | 553 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-147D22 | ZFIN Curated Data | |
| Encodes | EST | fc02c05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55667 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86919 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192852 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_144763 (1) | 2050 nt | ||
| Genomic | GenBank:CU181895 (2) | 65370 nt | ||
| Polypeptide | UniProtKB:A0A8M1PDD1 (1) | 553 aa |
- Magner, E., Sandoval-Sanchez, P., Kramer, A.C., Thummel, R., Hitchcock, P.F., Taylor, S.M. (2022) Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Molecular neurobiology. 59(5):2910-2931
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Silva, N.J., Nagashima, M., Li, J., Kakuk-Atkins, L., Ashrafzadeh, M., Hyde, D.R., Hitchcock, P.F. (2020) Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish. Glia. 68(7):1445-1465
- Nagashima, M., D'Cruz, T.S., Danku, A.E., Hesse, D., Sifuentes, C., Raymond, P.A., Hitchcock, P.F. (2019) Midkine-a is required for cell cycle progression of Müller glia glia during neuronal regeneration in the vertebrate retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(6):1232-1247
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Granneman, J.G., Kimler, V.A., Zhang, H., Ye, X., Luo, X., Postlethwait, J.H., Thummel, R. (2017) Lipid droplet biology and evolution illuminated by the characterization of a novel Perilipin in teleost fish. eLIFE. 6
- Thomas, J.L., Morgan, G.W., Dolinski, K.M., Thummel, R. (2017) Characterization of the pleiotropic roles of Sonic Hedgehog during retinal regeneration in adult zebrafish. Experimental Eye Research. 166:106-115
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
- Marín-Juez, R., Marass, M., Gauvrit, S., Rossi, A., Lai, S.L., Materna, S.C., Black, B.L., Stainier, D.Y. (2016) Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 113(40):11237-11242
- Sifuentes, C.J., Kim, J.W., Swaroop, A., Raymond, P.A. (2016) Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish. Investigative ophthalmology & visual science. 57:5148-5160
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