Gene
cygb1
- ID
- ZDB-GENE-020513-1
- Name
- cytoglobin 1
- Symbol
- cygb1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables nitrite reductase activity and oxygen binding activity. Acts upstream of or within neural crest cell development; regulation of neural crest cell differentiation; and response to cadmium ion. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including blood; brain; digestive system; head; and trunk neural crest. Orthologous to human CYGB (cytoglobin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cygb1 | Takahashi et al., 2020 | |
| CRISPR2-cygb1 | Rochon et al., 2023 | |
| CRISPR3-cygb1 | Schlosser et al., 2023 | |
| CRISPR4-cygb1 | Schlosser et al., 2023 | |
| MO1-cygb1 | N/A | Takahashi et al., 2020 |
| MO2-cygb1 | N/A | Takahashi et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin, lamprey/hagfish type | Globin-like superfamily | Globin/Protoglobin |
|---|---|---|---|---|---|---|
| UniProtKB:Q8UUR3 | InterPro | 174 | ||||
| UniProtKB:A0A0R4ITX9 | InterPro | 174 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-59F11 | ZFIN Curated Data | |
| Encodes | EST | fb77d07 | ZFIN Curated Data | |
| Encodes | EST | fb93a03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109806 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192982 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152952 (1) | 5217 nt | ||
| Genomic | GenBank:FP016106 (2) | 120535 nt | ||
| Polypeptide | UniProtKB:A0A0R4ITX9 (1) | 174 aa |
- Rochon, E.R., Xue, J., Mohammed, M.S., Smith, C., Hay-Schmidt, A., DeMartino, A.W., Clark, A., Xu, Q., Lo, C.W., Tsang, M., Tejero, J., Gladwin, M.T., Corti, P. (2023) Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nature communications. 14:83338333
- Schlosser, A., Helfenrath, K., Wisniewsky, M., Hinrichs, K., Burmester, T., Fabrizius, A. (2023) The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response. Biochimica et biophysica acta. Molecular cell research. 1870(8):119558
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Kim, S.H., Yang, D., Bae, Y.A. (2021) Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis. PLoS neglected tropical diseases. 15:e0009811
- Qiang, L., Cheng, J. (2021) Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio). Chemosphere. 263:128161
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Takahashi, K., Ito, Y., Yoshimura, M., Nikaido, M., Yuikawa, T., Kawamura, A., Tsuda, S., Kage, D., Yamasu, K. (2020) A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish. Developmental Biology. 472:1-17
- Amdahl, M.B., Petersen, E.E., Bocian, K.A., Kaliszuk, S.J., DeMartino, A.W., Tiwari, S., Sparacino-Watkins, C.E., Corti, P., Rose, J.J., Gladwin, M.T., Fago, A., Tejero, J. (2019) The zebrafish Cytochrome b5/Cytochrome b5 reductase/NADH system efficiently reduces Cytoglobins 1 and 2 - Conserved activity of Cytochrome b5/Cytochrome b5 reductases during vertebrate evolution. Biochemistry. 58(29):3212-3223
- Jia, Z.L., Cen, J., Wang, J.B., Zhang, F., Xia, Q., Wang, X., Chen, X.Q., Wang, R.C., Hsiao, C.D., Liu, K.C., Zhang, Y. (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 227:541-550
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