Gene

nek8

ID
ZDB-GENE-020509-1
Name
NIMA-related kinase 8
Symbol
nek8 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in heart looping; pronephros formation; and renal tubule development. Localizes to cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Fukui et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nek8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephronophthisis 9 Alliance ?Nephronophthisis 9 613824
renal-hepatic-pancreatic dysplasia Alliance Renal-hepatic-pancreatic dysplasia 2 615415
Associated With nek8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR044120 Nek8, catalytic domain
Homologous_superfamily IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Repeat IPR000408 Regulator of chromosome condensation, RCC1
Domain Details Per Protein
Protein Length Nek8, catalytic domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II Regulator of chromosome condensation, RCC1 Serine/threonine-protein kinase, active site
UniProtKB:A4FTZ5 697
UniProtKB:F1R1P5 697
UniProtKB:Q90XC2 697
UniProtKB:A0A0R4INL8 739
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations