Gene
nek8
- ID
- ZDB-GENE-020509-1
- Name
- NIMA-related kinase 8
- Symbol
- nek8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Acts upstream of or within heart looping; pronephros formation; and renal tubule development. Located in cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Fukui et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephronophthisis 9 | Alliance | ?Nephronophthisis 9 | 613824 |
| renal-hepatic-pancreatic dysplasia | Alliance | Renal-hepatic-pancreatic dysplasia 2 | 615415 |
| Polycystic kidney disease 8 | 620903 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nek8, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Regulator of chromosome condensation, RCC1 | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase NEK |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90XC2 | InterPro | 697 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available