Gene

vangl2

ID
ZDB-GENE-020507-3
Name
VANGL planar cell polarity protein 2
Symbol
vangl2 Nomenclature History
Previous Names
  • stbm (1)
  • strabismus (1)
  • tri
  • trilobite
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Involved in several processes, including embryonic morphogenesis; nervous system development; and regulation of Wnt signaling pathway. Localizes to plasma membrane. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
94 figures from 50 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vangl2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neural tube defects 182940
Associated With vangl2 Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO1-vangl2 standard conditions Leightner et al., 2013
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR009539 Vang-like protein
Domain Details Per Protein
Protein Length Vang-like protein
UniProtKB:Q8UVJ6 526
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vangl2 polyclonal IgG Goat
Santa Cruz Biotechnology, Inc.
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations