Gene

vangl2

ID
ZDB-GENE-020507-3
Name
VANGL planar cell polarity protein 2
Symbol
vangl2 Nomenclature History
Previous Names
  • stbm (1)
  • strabismus (1)
  • tri
  • trilobite
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Involved in several processes, including embryonic morphogenesis; nervous system development; and regulation of Wnt signaling pathway. Localizes to plasma membrane. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
104 figures from 53 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vangl2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neural tube defects 182940
Associated With vangl2 Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO1-vangl2 standard conditions Leightner et al., 2013
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR009539 Vang-like protein
Domain Details Per Protein
Protein Length Vang-like protein
UniProtKB:Q8UVJ6 526
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA vangl2-201 (1) Ensembl 5,862 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vangl2 polyclonal IgG Goat
Santa Cruz Biotechnology, Inc.
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations