Gene

vangl2

ID
ZDB-GENE-020507-3
Name
VANGL planar cell polarity protein 2
Symbol
vangl2 Nomenclature History
Previous Names
  • stbm (1)
  • strabismus (1)
  • tri
  • trilobite
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Involved in several processes, including embryonic morphogenesis; nervous system development; and regulation of Wnt signaling pathway. Localizes to plasma membrane. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
93 figures from 49 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vangl2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neural tube defects 182940
Associated With vangl2 Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO1-vangl2 standard conditions Leightner et al., 2013
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein Length
UniProtKB:Q8UVJ6 526
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vangl2 polyclonal IgG Goat
Santa Cruz Biotechnology, Inc.
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations