Gene
vangl2
- ID
- ZDB-GENE-020507-3
- Name
- VANGL planar cell polarity protein 2
- Symbol
- vangl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in several processes, including embryonic morphogenesis; nervous system development; and regulation of Wnt signaling pathway. Localizes to plasma membrane. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 105 figures from 54 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neural tube defects | 182940 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO1-vangl2 | standard conditions | Leightner et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR009539 | Vang-like protein |
Domain Details Per Protein
| Protein | Length | Vang-like protein |
|---|---|---|
|
UniProtKB:Q8UVJ6
|
526 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vangl2-201
(1)
|
Ensembl | 5,862 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vangl2 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids