Gene

lmnb1

ID

ZDB-GENE-020424-2

Name

lamin B1

Symbol

lmnb1 Nomenclature History

Previous Names

fc06g01
wu:fc06g01 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Human ortholog(s) of this gene implicated in atypical autosomal dominant adult-onset demyelinating leukodystrophy; autosomal dominant primary microcephaly 26; and typical adult-onset autosomal dominant demyelinating leukodystrophy. Orthologous to human LMNB1 (lamin B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55459 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lmnb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
atypical autosomal dominant adult-onset demyelinating leukodystrophy	Alliance	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, atypical	621061
typical adult-onset autosomal dominant demyelinating leukodystrophy	Alliance	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	169500
		Microcephaly 26, primary, autosomal dominant	619179

Associated With lmnb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR001322	Lamin tail domain
Domain	IPR039008	Intermediate filament, rod domain
Homologous_superfamily	IPR036415	Lamin tail domain superfamily

Domain Details Per Protein

Protein	Length	Intermediate filament protein, conserved site	Intermediate filament, rod domain	Lamin tail domain	Lamin tail domain superfamily
UniProtKB:Q803N8 InterPro	588
UniProtKB:F1QHC4 InterPro	588

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lmnb1-201 (1) Ensembl	Ensembl	2,975 nt	Select Tool ZFIN BLAST
mRNA	lmnb1-202 (1) Ensembl	Ensembl	3,021 nt	Select Tool ZFIN BLAST
mRNA	lmnb1-204 (1) Ensembl	Ensembl	779 nt	Select Tool ZFIN BLAST
mRNA	lmnb1-205 (1) Ensembl	Ensembl	1,037 nt	Select Tool ZFIN BLAST
mRNA	lmnb1-206 (1) Ensembl	Ensembl	1,919 nt	Select Tool ZFIN BLAST
ncRNA	lmnb1-004 (1) Ensembl	Ensembl	796 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations