Gene
lmnb1
- ID
- ZDB-GENE-020424-2
- Name
- lamin B1
- Symbol
- lmnb1 Nomenclature History
- Previous Names
-
- fc06g01
- wu:fc06g01 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be active in nuclear lamina. Human ortholog(s) of this gene implicated in atypical autosomal dominant adult-onset demyelinating leukodystrophy; autosomal dominant primary microcephaly 26; and typical adult-onset autosomal dominant demyelinating leukodystrophy. Orthologous to human LMNB1 (lamin B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55459 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant primary microcephaly 26 | Alliance | Microcephaly 26, primary, autosomal dominant | 619179 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Lamin tail domain | Lamin tail domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q803N8 | InterPro | 588 | ||||
| UniProtKB:F1QHC4 | InterPro | 588 |
Interactions and Pathways
No data available
Plasmids
No data available